Eccrine Systems, Inc.

Other

University of Cincinnati

Epicore Biosystems, Inc.

Jacob A Bertrand

Jason C Heikenfeld

Gavi Begtrup

Robert Beech

Austin Morgan

Richard J Ponton

Brian P Hanley

Nicholas Bailey

Michael Charles Brothers

Mikel Larson

Andrew Jajack

Nathan Weinle

Cory Newland

The invention includes a container for storing liquids, the container including a blending chamber for holding a larger volume of liquid, and an opening that can be selectively sealed or unsealed. The container also includes a sampling chamber for holding a smaller volume of liquid, and another opening that can be selectively sealed or unsealed. The blending chamber is located within and is at least partially surrounded by the sampling chamber. Fluidically connecting the blending chamber and the sampling chamber is a siphon having an upper opening in the blending chamber and a lower opening in the sampling chamber. The siphon includes a siphoning level, which is a fluid height in the blending chamber at which liquid will siphon from the blending chamber to the sampling chamber.

Automatic self-sampling bottle for spirits

The invention includes a container for storing liquids, the container including a blending chamber for holding a larger volume of liquid, and an opening that can be selectively sealed or unsealed. The container also includes a sampling chamber for holding a smaller volume of liquid, and another opening that can be selectively sealed or unsealed. Fluidically connecting the blending chamber and the sampling chamber is a siphon having an upper opening in the blending chamber and a lower opening in the sampling chamber. The siphon includes a siphoning level, which is a fluid height in the blending chamber at which liquid will siphon from the blending chamber to the sampling chamber. In some embodiments the siphon is located in the blending chamber.

The present invention provides a biofluid sensing device capable of concentrating a biofluid sample with respect to a target analyte, so that the analyte can be accurately detected or measured by EAB sensors. Methods for using such a device provide qualitative information about the presence of the analyte, and/or quantitative information about relative concentrations of the analyte in the biofluid. The disclosed device includes a concentration channel for concentrating the biofluid sample, as well as a selectively permeable membrane, one or more EAB sensors, and one or more secondary sensors carried on a water-impermeable substrate. A method for using the disclosed device to collect a biofluid sample, concentrate the sample relative to a target analyte, and measure the target analyte is also disclosed.

EAB sensing devices with biofluid sample concentration

Embodiments of the disclosed invention provide devices and methods to incorporate suspension-based, i.e., hydrogel-based and thixotropic compound-based, ion-selective electrodes and reference electrodes into a wearable sweat sensing device. Embodiments of this device are configured to monitor sweat electrolyte concentrations, trends, and ratios under demanding use conditions. The accompanying method includes use of the disclosed device to track fluid and electrolyte gain and loss in order to produce an electrolyte estimate, such as a sweat electrolyte concentration, a sweat electrolyte concentration trend, a sweat rate, or a concentration ratio between a plurality of electrolytes.

Sweat electrolyte loss monitoring devices

The disclosed invention provides sweat sensing devices with smart sweat stimulation and sensing embodiments: which improve the dependability and predictability of sweat sampling rates; achieve a desired number of sweat sampling events per day while minimizing skin irritation and prolonging device lifespan; and use physical, optical or thermal sweat stimulation to augment or replace chemical sweat stimulation.

Smart sweat stimulation and sensing devices

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

Devices capable of fluid sample concentration for extended sensing of analytes

The disclosed invention includes sweat sensing devices configured to periodically measure sweat conductivity and galvanic skin response, devices to measure volumetric sweat flow rate, and devices that combine the three functions. The disclosure further includes methods for using a device configured to perform periodic sweat conductivity measurements, galvanic skin response measurements, and volumetric sweat rate measurements so that each sensor modality informs composite estimates of sweat onset, sweat cessation, sweat ion concentration, and sweat rate. The method uses those measurements to inform other sweat sensing device functions, such as determining the existence of a physiological condition, or performing measurements of concentrations, ratios, and trends of sweat analytes.

Growing community of inventors

Norwood, OH, United States of America

Jacob A Bertrand