Kreatech Biotechnology B.v.

Leica Biosystems Newcastle Limited

Jacky Theo Maria Veuskens

Eduard Gerhard Talman

Robert Jochem Heetebrij

Franciscus Johannes Opdam

Robertus Petrus Maria Van Gijlswijk

Marie Lacombe

Franciscus Johannes Marie Opdam

The invention relates to a labeled transition metal complex comprising a transition metal atom, a reactive moiety for allowing a chemical or biological entity to become attached to the transition metal atom, an inert tridentate moiety as a stabilizing bridge, and a marker. The invention also relates to a labeled chemical or biological entity comprising a chemical or biological entity which is attached to said labeled transition metal complex, to the use of said complex for creating a defined shift in the molecular mass of said entity in order to facilitate mass spectrometric analysis of said entity, to methods for rendering chemical or biological entities distinguishable by mass spectrometry as well as to methods for mass spectrometric analysis of the chemical or biological entities. In addition, the present invention also relates to a set of at least two of said transition metal complexes of different molecular mass, to transition metal complexes comprising different stable isotopes, to chemical or biological entities obtained by a method of the invention and to a kit of parts supporting the use and/or methods of the invention.

Labeled transition metal complexes

The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit to employ a method according to the invention.

Differential labelling method

Growing community of inventors

Hasselt, Belgium

Jacky Theo Maria Veuskens