Laboratoire Francais Du Fractionnement Et Des Biotechnologies

Laboratoiore Francais Du Fractionnement Et Des Biotechnologies

Lfb Biotechnologies

Jacky Lirochon

Dominique Bourel

Abdessatar Chtourou

Roland Schmitthaeusler

Arnaud Glacet

Frédéric Dhainaut

Philippe Paolantonacci

Martine Bruley-Rosset

Abdessatar Sami Chtourou

The invention concerns a method for preparing human immunoglobulin concentrates for therapeutic use, from plasma or a plasma fraction. The method comprises pre-purification and a single anion-exchange chromatography carried out at alkaline pH, thereby enabling the immunoglobulins to be retained on the chromatographic support and fractionated. The method enables to obtain IgG, IgA and IgM concentrates.

Method for preparing human immunoglobulin concentrates for therapeutic use

The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The invention concerns Ig fractions having reactivity to IgM, IgG F(ab')2 or DNP hapten and no or little reactivity to non-self antigens, that is Ig fractions which have idiotypic interactions among themselves (connected fraction) or which include natural antibodies reacting with the DNP hapten. Said fractions exhibit a polyreactivity to specific autoantigens.

Ig fractions having immunomodulatory activity

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Breuillet, France

Jacky Lirochon