Colorado State University Research Foundation

University of Colorado

Jackson T Lewis

Travis S Bailey

Kristine Fischenich

Tammy Haut Donahue

Chen Guo

Richard Daniel Noble

Susan P James

Douglas L Gin

Ketul C Popat

David Alois Prawel

Matthew G Cowan

Richard L Koch

Dilanji Wijayasekara

Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.

Soft tissue mimetics and thermoplastic elastomer hydrogels

Provided herein is a block copolymer hydrogel, comprising a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO&#x2014;SOS by weight. The block copolymer hydrogel has a fatigue resistance to at least 500,000 compression cycles. Also provided are methods for forming the hydrogel.

Thermoplastic elastomer hydrogels

Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.

Synthetic polymeric materials and devices thereof

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Fort Collins, CO, United States of America

Jackson T Lewis