Paratek Pharmaceuticals, Inc.

Jackson Chen

Mark L Nelson

Mohamed Y Ismail

Kwasi Ohemeng

Beena Bhatia

Todd Bowser

Tadeusz Warchol

Peter Viski

Laura Honeyman

Joel Berniac

Haregewein Assefa

Paul Abato

Upul Keerthi Bandarage

Roger Frechette

Oak K Kim

Atul K Verma

Mark Grier

Ivan Yanachkov

Jingwen Pan

Victor Amoo

Rachid Mechiche

N Laxma Reddy

Jude Mathews

Oak Kim

The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

3, 10, and 12a substituted tetracycline compounds

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

Substituted tetracycline compounds

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.

Amino-methyl substituted tetracycline compounds

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Brookline, MA, United States of America

Jackson Chen