Ligand Pharmaceuticals, Inc.

Exelixis, Inc.

Jackline Eve Dalgard

Lin Zhi

Todd Anthony Miller

Dean Paul Phillips

Jyun-Hung Chen

Thomas Lau

E Adam Kallel

Matthew McNeill

Daniel A Ruppar

Raju Mohan

Richard Martin

Bao Vinh Nguyen

Venkataiah Bollu

Tie-Lin Wang

Brenton Todd Flatt

Ping Huang

Edwin J Schweiger

Bao Ngoc Nguyen

Richard Julius Penuliar

Richard J Penulian

A compound according to Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, Land X are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

11 &#x3b2;-HSD1 modulators

Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.

Thrombopoietin activity modulating compounds and methods

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Del Mar, CA, United States of America

Jackline Eve Dalgard