Carl Zeiss Microimaging Gmbh

Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud

Clarient Gmbh

Trestle Acquisition Corp.

Optimus Structures LLC

Jack Zeineh

Peter Ajemba

Gerardo Fernandez

Richard Jonathan Scott

Qiuhua Liu

Michael Donovan

Faisal Khan

Janakiramanan Ramachandran

Rui-Tao Dong

Usman Rashid

Terry Nolan Taylor

William L Davenport

Olga Smith

Richard Scott

A system and method that allows a user to interactively and iteratively create, manage, customize and price optimized annuity product composition is described.

System and method for optimizing annuity product composition and pricing

Apparatus, methods, and computer-readable media are provided for segmentation, processing (e.g., preprocessing and/or postprocessing), and/or feature extraction from tissue images such as, for example, images of nuclei and/or cytoplasm. Tissue images processed by various embodiments described herein may be generated by Hematoxylin and Eosin (H&E) staining, immunofluorescence (IF) detection, immunohistochemistry (IHC), similar and/or related staining processes, and/or other processes. Predictive features described herein may be provided for use in, for example, one or more predictive models for treating, diagnosing, and/or predicting the occurrence (e.g., recurrence) of one or more medical conditions such as, for example, cancer or other types of disease.

Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions

A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or 'virtual image.' In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of 'optical objectives' and &#x201c;virtual objectives.&#x201d; Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.

Intergrated systems and methods of virtual or live microscope slide presentation

A system and method for reconstructing a diagnostic trajectory.

System and method for reconstructing a diagnostic trajectory

A method of providing remote navigation of a specimen includes receiving a command to remotely control a microscope and a camera coupled with the microscope to view a portion of a specimen disposed on the microscope, capturing a digital image of the portion with the camera in response to the command, representing the digital image as a plurality of digital image components, each of the digital image components providing a different level of detail of the image, and transmitting the components in sequential order of increasing level of detail from least detailed to most detailed.

System and method for remote navigation of a specimen

Scanned image portions of virtual slide are stored in accord with a positional index metric associated to each image's location in a mosaic representation of the entire physical slide and a normalized correlation search is performed on next neighbor regional image blocks. A set of relative positional offset values and a correlation coefficient is determined for a regional image block and a next neighbor regional image block. A portion of the regional image blocks is viewed as a field of view of a display and a composite of the potion of regional image blocks is stitched together in accord with the set of relative positional offset values and the correlation coefficient, such that only the blocks comprising the portion are stitched. Moving the field of view of the display causes additional regional image blocks to be displayed, where image stitching is subsequently performed only with respect to the additional regional image blocks brought into the new field of view.

Systems and methods for stitching image blocks to create seamless magnified images of a microscope slide

A method and system for creating a digital, virtual slide having optimum image quality characteristics. Multiple regions of a physical slide are identified as well as at least two focus z-positions z, and zEach region of the physical slide is scanned (imaged) at the first z position, so as to produce a first set of digital images of each defined region. Each region of the physical slide is also scanned (imaged) at the second z position, so as to produce a second set of digital images of each defined region. Each image of each set is evaluated against a focus quality metric and, for each region, either the first or second image, corresponding to that region, is selected that exhibits a focus quality metric corresponding to a desired focus quality. These images are then merged into a digital virtual slide. Additional focus z-positions may be included, and the multiple z-positions may be scanned seriatim, sequentially, and/or in overlapping fashion.

System and method for creating magnified images of a microscope slide

A system and method for remote navigation of a specimen.

A system and method for visual image compression and transmission offers significant bandwidth conservation while retaining high resolution imaging capability. Videograpic images are decomposed into detail levels, and images are delivered to a remote site display at a level of detail proportional to the perception level of a viewer. Images are transformed, quantized, coded and queued for transmission in accordance with their level of image detail. Image detail layers are transmitted as an inverse function of image displacement speed and as a direct function of image magnification. Images are constructed vertically with each additional queueing layer providing additional image detail. Higher priority layers are lossy encoded, while the lowest priority layers (highest detail levels) are losslessly encoded.

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Fullerton, CA, United States of America

Jack Zeineh