Pharmacia & Upjohn Ab

Pharmacia & Upjohn Aktiebolag

Kabi Pharmacia Ab

Jack Spira

Thomas Osterberg

Lars Widlund

Marianne Mikaelsson

Lars Adamsson

Annelie B Almstedt

Helena Inga Sandberg

Helena Wiman

Catherine Ljung

Peter Lind

Brita Sjostrom

Mona Sydow-Backman

Eva Maria Gray (Hellstrom)

Method for treatment of hemophilia by extravascular administration of

Pharmaceutical formulation for subcutaneous intramuscular or intradermal

A DNA sequence coding for a biologically active recombinant human factor VIII derivative, comprising a first DNA segment coding for the amino acids 1 through 740 of human factor VIII and a second DNA segment coding for the amino acids 1649 through 2332 of human factor VIII, said segments being interconnected by a linker DNA segment coding for a linker peptide of at least 3 amino acid residues and up to about 10 amino acid residues which are selected from lysine and arginine; recombinant expression vector comprising such DNA sequence; host cells of animal origin transformed with such recombinant expression vector; a process for the manufacture of recombinant human factor VIII derivative; and human factor VIII derivative containing the heavy chain and the light chain linked by metal ion bond.

Recombinant human factor VIII derivatives

Method for obtaining an increased production of a producing cell line by

Growing community of inventors

Solna, Sweden

Jack Spira