Oncopeptides Ab

Sensidose Ab

Isifer Ab

Jack Spira

Fredrik Lehmann

Lars Tegborg

The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; β-cyclodextrin; ocyclodextrin; hydroxypropyl-β-cyclodextrin; sulfobutylether-β-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.

Lyophilized preparation of cytotoxic dipeptides

The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; &#x3b2;-cyclodextrin; ocyclodextrin; hydroxypropyl-&#x3b2;-cyclodextrin; sulfobutylether-&#x3b2;-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.

A pharmaceutical composition for treating infertility in a female subject substantially consists of local anesthetic of amide type such as lidocaine, human albumin, viscosity controlling agent selected from recombinant hyaluronic acid and combination of recombinant hyaluronic acid and water-soluble cellulose ether, optionally citrate, glucose, and/or amino acid, water optionally comprising one or more ions selected from the group consisting of sodium, potassium, magnesium, calcium, acetate, chloride, sulfate. Also disclosed is a method of treating infertility by administration of the composition to a female subject in need thereof.

Composition for treatment of infertility in a female subject

The present invention is directed towards a compacted powder shaped to comprise: a) a substantially annular girdle having opposing circumferential edges, the girdle having a diameter (x); and b) a dome protruding from each of the opposing circumferential edges of the girdle, wherein the height of each dome (hd) from the circumferential edge is, individually, about 0.18x to about 0.28x.

Compacted powder

The present invention is directed to lyophilized pharmaceutical preparations comprising melphalan flufenamide, or pharmaceutically acceptable salts thereof, and sucrose. Further independent claims are directed to methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment of cancer.

Lyophilized preparations of melphalan flufenamide

The present invention is directed to lyophilized pharmaceutical preparations comprising melphalan flufenamide, or pharmaceutically acceptable salts thereof, methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment of cancer.

A device for dispensing articles, the device comprising: a conveying member comprising n receptacles, of which n&#x2212;m are suitable for receiving articles, the receptacles being movable between an article receiving position and an article dispensing position; a sensor for sensing the presence of articles in the receptacles, the sensor positioned between the receiving position and the dispensing position; wherein m of said receptacles is a blank receptacle which is unable to receive an article and the sensor is unable to distinguish an empty receptacle from a blank receptacle such that the maximum number of detectable articles conveyed once n receptacles have passed the sensor is n&#x2212;m, where m is at least 1.

Growing community of inventors

Tyresö, Sweden

Jack Spira