Alcon Research, Ltd.

Alcon, Inc.

Altaviz, LLC

Novartis Ag

Alcon Pharmaceuticals Ltd.

Picocyl

Yamaha Hatsudoki Kabushiki Kaisha

Yamaha Motor Corporation, USA

Johnson & Johnson Surgical Vision, Inc.

Jack Robert Auld

John Christopher Huculak

Matthew Braden Flowers

Matthew D McCawley

John R Underwood

Christopher L McCollam

Marcus Antonio Souza

Ronald T Smith

Andrew T Schieber

James Lescoulie

Brian William McDonell

Timothy C Ryan

Eric N Anderfaas

Sudarshan B Singh

John C Dunne, Jr

Jose Luis Lopez

Tammo Heeren

Peter L Bliss

Xiaoyu Yu

Hien Nguyen

Michael McCulloch Martin

Steven Thomas Charles

Michael James Papac

Michael John Yadlowsky

Jason H Safabash

Lingfeng Yu

Ahmet Tezel

Mark Harrison Farley

Nader Nazarifar

Barry Lynn Wheatley

Dyson William Hickingbotham

Marshall Proulx

David M Weston

Deep Mehta

Salomon Valencia

Dean Banks

Ziad R Ghannoum

Matthew Douglas Mccawley

Christopher L Mccollam

Dean Lin

Dean Y Lin

Christopher Mccollam

Gregory E Mott

Harry Adam Dupre, Iii

Brian William Mcdonell

Michael Arthur Zica

Marcus Souza

Yule Kim

David Takashi Takamoto

Quinton A Quintana

Isabella L Hidalgo

Nicolas Welche

Michael A Zica

Chris Mudd

David T Takamoto

Dean W Banks

Andrew Scheiber

Andrew Thomas Schieber

Michael M Martin

Chetan Nirkhe

Marcus Souzda

Matthew Mccawley

Dyson W Hickingbotham

Canisters are provided that include a cylindrical body and a cap welded to the body to define a cavity filled with carbon dioxide or other fluid. The canisters may be loaded into a medical device, e.g., to provide an energy source for operating the device. Methods for making such canisters are also provided.

Gas canisters and methods for making them

Devices and methods are provided for delivering gas. In one example, the device includes a syringe body including a proximal end, a distal end including an outlet and a gas chamber communicating with the outlet, and a plunger carrying a piston slidably received within the syringe body. A canister containing a gas is provided within the plunger adjacent a passage through the piston communicating with the gas chamber. A drive actuator is movable to cause an opener pin to open a septum of the canister and release the gas, whereupon the gas travels through the passage into the gas chamber, thereby displacing the piston proximally to fill the gas chamber. Once activated, the plunger may be advanced to deliver the gas within the gas chamber through the outlet into a patient's body, e.g., into an eye via a cannula connected to the outlet.

Devices, systems, and methods for delivering gas

Systems, methods, and devices for inserting an intraocular lens (IOL) assembly into an eye may be provided. An example optic management system may include a housing having a first end and a second end and a first side extending between the first end and the second end. The housing may include a cavity formed in the first side of the housing and configured to accommodate an intraocular lens, wherein the cavity comprises a first end portion, a second end portion, and a central portion. The housing may further include a bore formed in the housing, wherein a first portion of the bore extends from the first end to the cavity. The haptic optic management system may further include a ceiling disposed on the first side of the housing. The haptic optic management system may further include arms pivotably coupled to the housing in the cavity.

Haptic optic management system utilizing rotary arms

An intraocular lens inserter can include a drive device with controllable advance motion. The drive device may include an actuator device and an energy device. The actuator device may include a piston rod that uses the advance motion to push an intraocular lens from a cartridge for insertion into an eye of an animal. The energy device may act upon the actuator device to generate the advance motion. The actuator device may include a dampening medium to control the advance motion, such as by controllably dampening the advance motion.

Intraocular lens inserter

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

Micro-volume injectors with dose guidance and methods for use

In some embodiments, a vitrectomy probe may include an inner cutting tube reciprocating in an outer tube. The outer tube includes a side port and the inner tube includes a distal cutting port, and, in some embodiments, an additional side port. In some embodiments, the inner tube may also include a flat upper edge that cuts across the outer tube side port. In some embodiments, a diaphragm drives the inner tube and may have an open-stroke side with a lower hardness material than a closed-stroke side. In some embodiments, an aspiration tube coupled to the vitrectomy probe may include a first aspiration tubing and a second aspiration tubing with a lower hardness than the first aspiration tubing. In some embodiments, the vitrectomy probe may be coupled to pneumatic tubing that is stepped or tapered.

Vitrectomy probe

Devices and methods are provided for delivering fluid into a patient's body. In an exemplary embodiment, the device may include a syringe cartridge and a syringe driver that may be coupled to the cartridge. The cartridge may include a housing including a proximal end, a distal end, and defining an interior, the cartridge further including a piston slidably disposed within the interior for delivering fluid within the interior through a port in the distal end. The driver may include a plunger for advancing the piston within the interior of the housing, a source of pressurized fluid, a valve, and an actuator member coupled to the valve for selectively opening a flow path from the source to the plunger to control flow of the pressurized fluid to advance the plunger to deliver fluid from the interior of the housing at a desired rate.

Self-powered syringe drivers

Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.

Injection devices and methods for making and using them

Systems, methods, and devices for inserting an intraocular lens (IOL) into an eye may be provided. In an exemplary aspect, the present disclosure is directed to a haptic optic management system. The haptic management system may include a housing that includes a bore and a cavity disposed in a first surface of the housing. The cavity may include a first end portion, a second end portion, and a central portion, wherein the cavity provides access to the bore through the first surface of the housing. The haptic management system may include arms coupled to the housing. The haptic management system may include edge rollers coupled to the housing.

Haptic optic management system utilizing edge rollers

A gas mixture apparatus includes a measurement control system, an activation system, a pressurized chamber with one or more gases, and a mixing chamber. A filter can be preattached to an outlet of the mixture apparatus, allowing excess gas to be discharged therethrough and then atmospheric air to be drawn into the mixture apparatus through the filter for creating a therapeutic gas mixture.

Intraocular gas injector

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes an injector cannula having a soft injector tip. A retractable tip protector tube is slidably disposed on the flow cannula between an extended position in which the tip protector tube covers the entire injector tip, and a retracted position in which the tip protector tube is retracted proximally thereby exposing at least part of the injector tip. Accordingly, the tip protector tube protects the injector tip from being damaged while advancing the injector tip to a target injection site.

Soft tip cannula with retractable tip protector

Systems, methods, and devices for inserting an intraocular lens (IOL) assembly into an eye may be provided. An example optic management system may include a housing having a first end and a second end and a first side extending between the first end the second end. The housing may include a cavity formed in the first side of the housing and configured to accommodate an intraocular lens, wherein the cavity comprises a first end portion, a second end portion, and a central portion. The housing may further include a bore formed in the housing, wherein a first portion of the bore extends from the first end to the cavity. The haptic optic management system may further include a ceiling disposed on the first side of the housing. The haptic optic management system may further include arms pivotably coupled to the housing in the cavity.

Growing community of inventors

Laguna Niguel, CA, United States of America

Jack Robert Auld