Adamas Pharmaceuticals, Inc.

Northwestern University

Cavalon Therapeutics, Inc.

Jack Nguyen

Timothy J Fultz

Gregory T Went

David Chernoff

Terry L Burkoth

Sangita Ghosh

Mickey S Urdea

Rowan Chapman

Paul Spence

Dalton James Surmeier, Jr

The present disclosure provides extended or sustained release compositions of a dihydropyridine calcium channel blocker, specifically isradipine, and method of using the compositions for the treatment of neurological disorders, wherein the composition provides sustained plasma levels of the dihydropyridine calcium channel blocker.

Dihydropyridine compositions and methods for treating neurological disorders

Compositions and methods are provided for administering a pharmaceutical composition to a human patient. Compositions are administered to a human patient orally, once daily, at a therapeutically effective dose. The pharmaceutical compositions comprise a drug selected from the group consisting of brivaracetam, divalproex, lacosamide, levetiracetam, oxcarbazepine, vigabatrin, and pharmaceutically acceptable salts of any of the foregoing, and at least one excipient. At least one of said at least one excipients modifies the release of said drug to provide an extended release form. The pharmaceutical composition have pharmacokinetic properties recited in the claims.

Methods and compositions for the treatment of seizure-related disorders

Kits comprising an M2 inhibitor selected from amantadine and rimantadine; ribavirin, and a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin and a neuraminidase inhibitor are provided for the treatment of influenza. Some embodiments of the kits comprise an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin, and a neuraminidase inhibitor.

Compositions and kits for treating influenza

Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.

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Berkeley, CA, United States of America

Jack Nguyen