Rigel Pharmaceuticals, Incorporated

Rapt Therapeutics, Inc.

Newgen Therapeutics, Inc.

Exelixis, Inc.

Rakovina Therapeutics Inc.

Jack Maung

Yan Chen

Kin Tso

Rajinder Paul Singh

Hui Li

Vanessa Taylor

Thilo J Heckrodt

Rose Yen

Darren J McMurtrie

Ryan Kelley

Wang Shen

Xiaoling Zheng

Aimin Zhang

Jacob Bradley Schwarz

David Juergen Wustrow

Akinori Okano

Dennis X Hu

Paul Robert Leger

Xinping Han

Grant Masaaki Shibuya

Berenger Biannic

Kyle Young

Esteban Masuda

Wei Xu

Yong Wang

Simon Shaw

Hunter Paul Shunatona

Lynne Canne Bannen

Mikhail Zibinsky

John Michael Ketcham

Wei Xiao

Zhenzhong Wang

Anton Shakhmin

Minna Bui

Jeffrey J Jackson

Omar Robles

Faming Jiang

Gene Cutler

Adrian O Dukes

Anqi Ma

Andrew A Ng

Yoo Min Ko

Qingming Guo

Yingguang Li

David Sweeny

Justin Salvant

Benjamin Spangler

Andrew Raub

Yamini Ohol-Gupta

Minna H T Bui

Darren Mcmurtrie

Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitor compounds and compositions comprising such compounds. The compounds may have a structure according to Formula I Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Pyrimid-2-yl-pyrazole compounds as IRAK inhibitors

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

Pyridone compounds and methods of use

Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

IRAK inhibitors and method for making and using

The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).

Alkyne substituted quinazoline compound and methods of use

Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Pyrazole compounds and methods for making and using the compounds

The invention provides for compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. The compounds are potent inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), particularly PARP-1 and potentially PARP-2. The also show good cellular activity in inhibiting poly(ADP-ribose) oligomer formation. The compounds may be useful as mono-therapy or in combination with other therapeutic agents in the treatment conditions where PARP is implicated, such as cancer, inflammatory diseases and ischemic conditions. Thus, also provided are methods for the treatment of a condition where PARP is implicated comprising administering to an effective amount of a compound of the invention to an individual in need thereof.

Tricyclic inhibitors of poly(ADP-ribose)polymerase

Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.

Ubiquitin-specific-processing protease 7 (USP7) modulators and uses thereof

Disclosed herein are pyrozolo-pyrimidin-amino-cycloalkyl compounds, analogs thereof, pharmaceutical compositions comprising thereof and therapeutic uses therefor.

Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses

Pyrazole compounds and method for making and using the compounds

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Daly City, CA, United States of America

Jack Maung