General Electric Company

Jack Mathew Webster

Faisal Ahmed Syud

Rong Zhang

Vasile Bogdan Neculaes

Bruce Allan Hay

Brian Duh-Lan Lee

Bruce Fletcher Johnson

James William Bray

John Frederick Graf

Yuri Alexeyevich Plotnikov

Yongjae Lee

Michael James Rishel

Nilesh Tralshawala

Kande Kankanamalage Dayarathna Amarasinghe

William Chester Platt

Chittari Pabba

Paul Schaffer

Aghogho Atemu Obi

Sarah Lillian Katz

Seog Tae Kim

Joshua Kendall Hoerner

Jennifer Lynne Huntington

Kande Kankanamalage Amarasinghe

Jennifer Huntington

Kande Kankanamalage Dayara Amarasinghe

Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

Labeled molecular imaging agents and methods of use

A calorie estimating device for measuring a calorie content of a food item is provided. The device comprises a holder substrate, a transmitter antenna configured to transmit ultra-wide band (UWB) signals to at least a portion of the food item disposed on a side of the holder substrate, wherein the transmitter antenna comprises a planar antenna, a first receiver antenna configured to receive at least a portion of UWB signals reflected by the food item, wherein the first receiver antenna comprises a planar antenna, and a second receiver antenna configured to receive at least a portion of UWB signals propagated through the food item, wherein the second receiver antenna comprises a planar antenna.

Systems and methods for non-destructively measuring calorie contents of food items

A system for measuring nutritional parameters of food items is provided. The system includes a holding cavity. The system further includes a sensor assembly that includes a transmitter antenna and at least one receiver antenna. The transmitter antenna is configured to transmit signals to a food item in the holding cavity. The receiver antenna is configured to receive response signals from the food item. The system includes at least one switch coupled to each antenna. The switch, in a first state, is configured to set the sensor assembly to an electric potential equal to that of the holding cavity. In a second state, the switch is configured to couple the sensor assembly to a power source. The system also includes a processing unit to process the signals received to determine the nutritional parameters of the food item.

System and method for detection of nutritional parameters in food items

Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.

Labeled molecular imaging agents, methods of making and methods of use

Provided herein are isolated polypeptides derived from theprotein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.

Two helix binders

An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of different natural amino acid mutations in the polypeptide are provided here. Also provided are methods of using the two-helix binders.

An isolated polypeptide, Z domain, derived from B domain ofprotein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.

An isolated polypeptide, Z domain, derived from B domain ofprotein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an un-natural amino acid in the polypeptide is provided here. Also provided are methods of using the two-helix binders.

An isolated polypeptide, Z domain, derived from B domain ofprotein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.

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Colonie, NY, United States of America

Jack Mathew Webster