Picolight, Inc.

Quantum-si Incorporated

Vixel Corporation

At&t Bell Laboratories

Jds Uniphase Corporation

American Telephone & Telegraph Co., At&t Bell Laboratories

Photonics Research Incorporated

Bandgap Technology Corporation

Other

Bell Communications Research, Inc.

The United States of America As Represented by the Secretary of

Picolight Incoporated

Jack L Jewell

Jonathan Marc Rothberg

Lawrence Camest West

Jason W Sickler

Paul E Glenn

Benjamin Cipriany

Keith Glen Fife

Farshid Ghasemi

Henryk Temkin

Todd Rearick

Gerard M Schmid

Jeremy Christopher Jordan

Jeremy Lackey

Ali Kabiri

Jonathan C Schultz

Faisal R Ahmad

John Glenn

Jose Camara

Gregory R Olbright

Brett J Gyarfas

Stanley E Swirhun

Michael Ferrigno

Greg R Olbright

Anthony Bellofiore

Andrew Moore

Mikhail Kaluzhny

Adam Ezra Cohen

Robert P Bryan

Samuel L McCall, Jr

Boris J Muchnik

Axel Scherer

David A Miller

Thomas J Cloonan

William E Quinn

Frederick B McCormick, Jr

Kuochou Tai

Luke A Graham

Michael E Prise

Stan E Swirhun

Gaylord W Richards

Anthony L Lentine

Kyle Preston

James Beach

Stephen Joseph Hinterlong

Harvard S Hinton

Frank K Hwang

Kevin L Lear

Jurgen Jahns

Stephen D Walker

Dennis G Deppe

Jonathan M Rothberg

Peter Esherick

Miles J Murdocca

Kai-Feng Huang

Winston S Fu

Akira Tomita

Alexander Gondarenko

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

Optical system and assay chip for probing, detecting and analyzing molecules

Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.

Compact mode-locked laser module

Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.

Pulsed laser and bioanalytic system

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.

Integrated device with external light source for probing detecting and analyzing molecules

An integrated device and related instruments and systems for analyzing samples in parallel are described. The integrated device may include sample wells arranged on a surface of where individual sample wells are configured to receive a sample labeled with at least one fluorescent marker configured to emit emission light in response to excitation light. The integrated device may further include photodetectors positioned in a layer of the integrated device, where one or more photodetectors are positioned to receive a photon of emission light emitted from a sample well. The integrated device further includes one or more photonic structures positioned between the sample wells and the photodetectors, where the one or more photonic structures are configured to attenuate the excitation light relative to the emission light such that a signal generated by the one or more photodetectors indicates detection of photons of emission light.

Optical rejection photonic structures using two spatial filters

A device comprising: an optical subassembly has a lens rear surface including one or more facets for scattering at least some of the light transmitted through the lens rear surface.

Low-noise optical transmitter

Growing community of inventors

Boulder, CO, United States of America

Jack L Jewell