Syngenta Corporation

Jack Hugh Vass

Alan John Whitton

Ewan Campbell Boyd

Gillian Beveridge

Gillan Beveridge

The present invention relates, inter alia, to a process for preparing a compound of formula (I): using, as a catalyst 1,4-diazabicyclo[2.2.2]octane. 

Preparation of azoxystrobin

The present invention relates, inter alia, to a process for preparing a compound of formula (I): using a quinuclidine-based catalyst or an optionally 3-substituted N-methyl pryrrolidine-based catalyst. 

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The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(COCH)&#x2550;CHOCHor the methyl 2-(3,3-dimethoxy)propanoate group C(COCH)CH(OCH), or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them. 

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Grangemouth, United Kingdom

Jack Hugh Vass