Washington University

Jack H Ladenson

Vijay Modur

Omar Laterza

Yvonne Landt

Dan Crimmins

Pampee P Young

Hermant C Vaidya

David N Dietzler

Ann Y Maynard

Joseph P Gaut

Ruth Ladenson

The invention relates to compositions and methods for detecting renal injury in a subject, such as proximal tubular injury associated with acute kidney injury.

Miox antibody and assay

Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed.

Markers for brain damage

Evaluation of VLP-I levels in combination with at least one of amyloid-&#x3b2; peptide (AB), hyperphosphorylated tau (pTau) or total tau (tTau) levels in samples of biological fluid improves the accuracy of diagnosis of Alzheimer's disease.

Alzheimer's diagnosis

A method for aiding in the determination of whether a living or deceased human is afflicted with or will likely have atherosclerosis respectfully, the method comprising determining the level of SPRR3 protein in a intimae or body fluid sample by using molecular localization analysis technique comparing the determined level of SPRR3 protein in the biological sample obtained from said individual with a range of SPRR3 levels previously defined as characteristic for humans having atherosclerosis, concluding from the comparison that the person is likely suffering from atherosclerosis when a SPRR3 level is in the range previously defined as characteristic for the presence of atherosclerosis as an indication that the individual is suffering from or has suffered from atherosclerosis.

Method of assessing the risk of atherosclerosis

Single-chain, camelized heavy chain antibodies immunospecific for caffeine and stable at high temperatures are useful for analysis and recovery of caffeine in or from fluids. A device that provides a single-step lateral flow assay for caffeine and a useful peptide spacer are also described.

Methods for determining and lowering caffeine concentration in fluids

A method of determining CK-MB isoenzyme in a biological fluid is disclosed which comprises subjecting a sample of said fluid to an assay system which includes incubating with monoclonal antibody specific to CK-MB isoenzyme, but not reactive with CK-MM or CK-BB. Methods for preparing antibodies with these characteristics and cell lines producing them are also disclosed.

Growing community of inventors

University City, MO, United States of America

Jack H Ladenson