Symbollon Corporation

Other

Iotech International, Incorporated

Abbott Molecular Inc.

Gene-trak Systems

I2pure Corp.

Becton Dickinson and Company Limited

Iogen Corporation

Biopharmx, Inc.

Jack H Kessler

Dwight Livingston

Mark A Talmer

Robert L Campbell

Thomas D Haubert

Ammon David Lentz

James A Prescott

Michael L Marshall

Gregory S Kramer

Rodger Elliot Kolsky

Joseph P Skinner

Michael Justin Lizzi

Scott Nicholas Danhof

Robert S Rosenbaum

James C Richards

James Carlton Richards

David C Litzinger

Melody M H Kuroda

M Scott Ulrich

Artis R Lockhart

Sonal Sadaria Nana

Frank Pawlowski

May K Li

Rick Panicucci

Kristin Weidemaier

Adam C Curry

Andrea Liebmann-Vinson

Eric Fallows

Kirk Raymond Dinehart

Kevin G Dolan

David S Sebba

Randy J Somerville

Donald E Gorelick

Ernie Ritchey

David T Bach

Miroslaw Bartkowiak

Yongjun Duan

John Hickey

Spencer Lovette

Wendy Dale Woodley

Herbert Moskowitz

Christopher A Rhodes

Erin Gooch Carruthers

Andrew M Cerro

Jeffrey S Ojala

Elaine Palome

Donna McLaughlin

Robert Kehl Sink

John J Hickey

Eugene Duan

Eric A Fallows

Melody MH Kuroda

Embodiments of high molecular iodine concentration composition and pharmaceutical formulation are disclosed, which may be biostatic persistent, biocidal persistent, and have prolonged biocidal activities against microorganisms for hours after administration of the composition or pharmaceutical formulation. Articles comprising high molecular iodine concentration composition and pharmaceutical formulation, as well as preparation and use of same are also disclosed.

High molecular iodine concentration compositions, pharmaceutical formulations, preparation and uses

The instant disclosure provides methods of multi-assay processing and multi-assay analysis. Such multi-assay processing and analysis pertain to automated detection of target nucleic acids, e.g., as performed in the clinical setting for diagnostic purposes. Also provided are common assay timing protocols derived from a variety of individual nucleic acid amplification and analysis protocols and modified to prevent resource contention. The instant disclosure also provides systems and devices for practicing the methods as described herein.

Methods and systems of multi-assay processing and analysis

The present invention is directed to a composition in solution (often, an aqueous solution) which comprises a combination of molecular iodine (I) and an acceptable source of iodate (IO), and an acid (inorganic or organic), wherein iodide and iodate are present in the composition at a molar ratio of about 0.1 to about 25, the concentration of uncomplexed molecular iodine is a disinfectant, biocidal and/or antimicrobial (depending upon the end use of the composition) effective amount the concentration of acid in the composition is effective to provide a buffering pH in the composition ranging from about 1.5 to about 6.5. Compositions according to the present invention are storage stable for unexpectedly long periods of time (up to about 5 years), and find use as disinfecting solutions, as germicides and/or biocides (e.g. antiviral, antibacterial, antifungal, antispore etc.) for various surfaces and solutions including living and inanimate surfaces and are particularly useful because of their low cost, their reduced use of iodine, their activity (because of the high concentration of free molecular iodine in solution), their reduced environmental impact, their long term storage stability and their reduced toxicity. They also have particular utility in treating food surfaces to retard spoilage, increase useful shelf-life and minimize the human and economic cost of food waste. The compositions inactivate viruses, bacteria (both gram negative and positive), spores and fungi. Compositions according to the present invention may be used and stored in a variety of materials, given the substantial absence of corrosion (non-corrosive) these compositions display. Dental compositions (e.g. preprocedure rinses and other compositions) and methods related thereto are also disclosed.

Stable compositions of uncomplexed iodine and methods of use

This invention relates generally to an emollient topical composition of matter that contains molecular iodine with a reduced effective vapor pressure. In specific embodiments, the composition reduces the loss of molecular iodine to the atmosphere under storage conditions after application to mammalian tissue.

Emollient topical disinfectants

The present invention is directed to a composition in solution (often, an aqueous solution) which comprises a combination of molecular iodine (I) and an acceptable source of iodate (IO), and an acid (inorganic or organic), wherein iodide and iodate are present in the composition at a molar ratio of about 0.1 to about 25, the concentration of uncomplexed molecular iodine is a disinfectant, biocidal and/or antimicrobial (depending upon the end use of the composition) effective amount the concentration of acid in the composition is effective to provide a buffering pH in the composition ranging from about 1.5 to about 6.5. Compositions according to the present invention are storage stable for unexpectedly long periods of time (up to about 5 years), and find use as dis infecting solutions, as germicides and/or biocides (e.g. antiviral, antibacterial, antifungal, antispore etc.) for various surfaces and solutions including living and inanimate surfaces and are particularly useful because of their low cost, their reduced use of iodine, their activity (because of the high concentration of free molecular iodine in solution), their reduced environmental impact, their long term storage stability and their reduced toxicity. They also have particular utility in treating food surfaces to retard spoilage, increase useful shelf-life and minimize the human and economic cost of food waste. The compositions inactivate viruses, bacteria (both gram negative and positive), spores and fungi. Compositions according to the present invention may be used and stored in a variety of materials, given the substantial absence of corrosion (non-corrosive) these compositions display. Dental compositions (e.g. preprocedure rinses and other compositions) and methods related thereto are also disclosed.

Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.

Methods, systems, and devices for detecting and identifying microorganisms in microbiological culture samples

The invention is a solid oral dosage form that is designed to deliver a supraphysiological dose of molecular iodine of 3 to 60 mg per day. The solid oral dosage form is designed to have a low risk of thyroid related adverse clinical events for patients with deficiencies of certain minerals. The solid oral dosage form includes a source of iodine, a reactive agent, and calcium or iron. The solid oral dosage form may include one or more of selenium, vitamin A, vitamin D, zinc, gamma-linolenic acid, vitamin B1, and magnesium. The solid dosage form may further comprise an enteric coating that coats ingredients that are absorbed predominantly from the intestines, such as vitamin A and D, and does not coat the source of iodine and the reactive agent.

Solid oral dosage form for breast symptoms

A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of Iand Icomprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.

Methods for inhibiting the activation of immune cells

A shoe cleaning doormat device is provided for cleaning and disinfecting the soles of shoes and feet prior to a user's entry into a dwelling or building. The device is a doormat having a cleaning assembly having a disinfecting cleaning material surface and drying portions. Both portions are housed within a mat frame and exposed to a user through cutouts in the mat's upper surface. A disposable roll of moist, disinfecting wipe material provides the cleaning and disinfecting surface. An advancing button is operatively connected to the roll so that a user may obtain an unused portion of the roll by depressing the button. After shoes or feet are cleaned, they can be dried by rubbing on the drying portions of the device, which comprise a removable, moisture-absorbing material.

Shoe cleaning doormat device

A method for killing or substantially eradicating a pathogen in the upper respiratory tract of a mammal is disclosed. The method comprises generating molecular iodine (I2) in situ using an oxidant-reductant reaction with a minimum concentration of at least about 25 ppm of I2 and I2 comprises at least 40% of the total iodine atoms. A method for inhibiting superantigens using molecular iodine is also disclosed.

[object Object]

Non-staining topical iodine disinfecting compositions having the ability to inactivate pathogens associated with skin infections or diseases. based upon the presence of molecular iodine in a concentration above at least 15 ppm. Any other iodine species selected from the group consisting of complexed iodine and triiodide may be present with the total of such other iodine species limited to a concentration of less than about 700 ppm so that any visible stain resulting from the application of this composition on the skin will dissipate without leaving any visible skin coloration.

Non-staining topical iodine composition and method

A stabilized solid oral pharmaceutical composition comprised of iodide and iodate as the active agents in the presence of one or more pharmaceutical excipients and a method for preparing these stabilized compositions.

Stabilized oral pharmaceutical composition containing iodide and iodate and method

Growing community of inventors

Southborough, MA, United States of America

Jack H Kessler