Eli Lilly and Company

Jack F Wagner

David B Anderson

James L Hudson

The concentration of endogenous growth hormone in the bloodstream of an economic mammal is increased by the simultaneous administration of an estrogen and a growth hormone releasing factor.

Synergistic treatment method

This invention describes a method of increasing the feed intake of pigs, chickens, or dairy cattle, which have elevated levels of growth hormone, by administering a thyroid-active substance.

Growth hormone and thyroid hormone

There is disclosed an implant which has an inert, biocompatible core with a coating comprising from about 5 to about 40% of estradiol in a biocompatible dimethylpolysiloxane rubber. When the implant is placed under the skin of a ruminant animal the estradiol is released at a substantially constant rate to produce a greater than normal weight gain in the animal. The implant remains intact and may be removed from the animal at the end of the desired period of drug administration.

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Greenfield, IN, United States of America

Jack F Wagner