Large Scale Proteomics Corporation

Other

Igen International, Inc.

Large Scale Biology Corporation

Chevron Research Company

Igen, Inc.

Optelecom, Inc.

Bioveris Corporation

Eisai Company, Limited

Technology Recognition Systems, Inc.

Jack E Goodman

N Leigh Anderson

Norman G Anderson

Jonathan K Leland

John H Kenten

Richard J Massey

Gary F Blackburn

Haresh P Shah

George E Lowke

Yuzaburo Namba

Glenn D Zoski

John T Grosser

Ali Ghaed

John K Leland

Donald C Schmadel

John T Bennett

Andrew McGrath

David G Mateer

Abraham Ingber

Gordon Gould

John Joseph Lennon

Samuel G Michael

Jeffrey S Coffin

Matthew A Torres

Hongjun Yang

L Eric Wallgren

Ali Ghead

Ian Stuart Richard Smith

An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.

Methods and apparatus for improved luminescence assays

A system for performing hybridization assays comprises a cartridge for housing a flow through device, where the cartridge includes a test fluid chamber for facilitating a substantially uniform flow of a test fluid mixture through the flow through device, and a fluidics station to deliver the test fluid mixture to the cartridge. The cartridge has a chip holder that holds the flow-through device, which has an array of microchannel passages. The chip holder has a support for placement of the flow though device, the test fluid chamber for directing a substantially uniform flow of a test fluid mixture through the array of microchannel passages of the flow through device, and a first port that receives the test fluid mixture. The cartridge has a sealing system for preventing the leakage of the test fluid around the flow through device. The test fluid chamber is defined in part by a spade-like surface having an inlet for the test fluid mixture.

Flow-thru chip cartridge, chip holder, system and method thereof

An automated, computer controlled assembly is provided for continuously processing a large number of electrophoresis gels. The assembly includes a loading assembly for loading a gel onto a carrier, a gel staining assembly and a scanning and cutting assembly. The staining assembly and the scanning and cutting assembly each include a robotic arm that is able to capture a gel and transfer the gel to selected work stations and can transfer the gel between the respective robotic arms.

Automated electrophoresis gel manipulation apparatus

Method and tool for fracturing the cement interface between a crown and a tooth or the like. The method is accomplished by positioning a piezoelectric driven rapid impacting tool against one side of a portion of a crown covering the tooth. The tool is covered with a malleable metal and is interfacing abutment with said crown. The opposite side of the crown is abutted against an anvil which is covered with a thicker malleable metal interface.

Method for removing a dental crown and apparatus therefor

The invention provides compositions and kits for performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence. The compositions and kits comprise an electrochemiluminescent label, collectable particles, binding reagents, and an electrolyte.

Electrochemiluminescent localizable complexes for assay compositions

An apparatus for expressing and unloading an isoelectric focusing gel from an electrophoresis gel tube includes a first support for supporting the gel tube, a plunger rod and a second support for supporting the plunger rod. The first support is mounted on a movable carriage and is moved toward the second support so that the gel tube slides onto the plunger rod to unload the gel from the gel tube. A plurality of gel tubes can be mounted in a rack and the rack coupled to the first support. The first support preferably includes a plurality of openings oriented with the gel tubes for guiding a respective plunger rod through the axial passage of the gel tubes. In preferred embodiments, the second support supporting the plunger rods is substantially stationary while the first support moves toward the second support so that the gel tubes slide onto the plunger rods. A plunger member such as a rubber ball is positioned in the axial passage of the gel tubes between the gel and the plunger rod to unload the gel in a substantially uniform manner without tearing or breaking the gel.

Method and apparatus for unloading gels from isoelectric gel tubes

An automated assembly for performing first dimension electrophoresis is described herein that includes a supply magazine, an electrophoresis tank and an automated transferring device that robotically transfers biological samples from sample vials retained in the supply magazine, and delivers the biological samples one by one to tube gels supported in a rack within the electrophoresis tank. The transferring device is configured to move in three dimensions with respect to the supply magazine and the rack for flexible sample delivery.

Automated apparatus including a robotic arm for loading samples into wells for first dimension electrophoresis separation

An automated high-throughput system for excising spots or samples from an electrophoresis slab gel includes a computer controlled robotic arm assembly and a sample plate handling assembly for supplying a sample plate to a loading station. The computer is connected to a scanner and imaging device to identify selected sample locations on the slab gel and to direct the robotic arm to the selected locations for excising the gel spots. The cutting assembly includes a removable tray for supporting the slab gel during the cutting process and is coupled to the automated sample plate handling assembly. The sample plate handling assembly delivers a multiwell plate to the cutting assembly for receiving the gel spots. The removable tray cooperates with a scanner for identifying protein spots and includes a positioning device to position the tray in the scanner and the cutting assembly in selected locations to coordinate the scanned image with the cutting process.

Automated apparatus for separating a biological sample from a two dimensional electrophoresis gel

The present invention provides an integrated, fully automated, high-throughput system for two-dimensional electrophoresis comprised of gel-making machines, gel processing machines, gel compositions and geometries, gel handling systems, sample preparation systems, software and methods. The system is capable of continuous operation at high-throughput to allow construction of large quantitative data sets.

Apparatus for computer-assisted isolation and characterization of proteins

Automated system for two-dimensional electrophoresis

An automated apparatus for carrying out a first dimension electrophoresis separation of proteins and other macromolecules includes a supply magazine, an automated transferring device and an electrophoresis tank. The supply magazine includes a carousel for storing sample containers, a bar code reader, a holding device and an arm for transferring the sample container from the carousel to the bar code reader and the holding device. The transferring device includes a reciprocating pipette that is able to remove a sample from a sample container and deliver the sample to a selected gel tube in the electrophoresis tank. The tank includes a rack supporting a plurality of gel tubes and includes a chamber for containing a buffer solution in contact with one end of the gel tubes. The chamber includes a top wall with an opening having a guide surface for guiding the pipette through the chamber to the top end of the gel tubes.

First dimension electrophoresis separation method and apparatus

A gel slab sealing strip adapted for use in an electrophoresis tank is provided according to the invention. The sealing strip includes a body having a height, at least one flap extending outwardly from the body and having a height substantially equal to the body, and a core extending at least partially through the body, wherein the sealing strip is adapted to be inserted into a corresponding receptacle in a bottom of the electrophoresis tank.

Gel slab sealing strip for an electrophoresis tank

An alignment plate is provided with a plurality of holes for guiding a pipette tip toward a sample plate of a MALDI mass spectrometer. Each of the holes is provided with a conical upper contour in order to guide the pipette tip toward a specific location on the sample plate. Two companion alignment plates are used in order to overlay two separate arrays of samples on the sample plate. For instance, a first of two alignment plates is formed with a 10&times;10 array of holes so that a 10&times;10 array of samples is deposited by the pipette tip onto the sample plate. The second of the two alignment plates is formed with a 9&times;9 array of holes so that a 9&times;9 array of samples is deposited on the sample plate at locations offset from the 10&times;10 array of samples already on the sample plate. The number of samples loaded on the sample plate is large and the space on the sample plate is more fully utilized.

Devices for use in MALDI mass spectrometry

Two-dimensional gels for separation, identification and characterization of biomolecules

Growing community of inventors

Arlington, VA, United States of America

Jack E Goodman