Roche Colorado Corporation

Other

Boehringer Ingelheim International Gmbh

F. Hoffmann-la Roche Ag

Jack Delbert Brown

Peter John Harrington

Hiralal N Khatri

Richard Robert Dauer

Robert J Topping

Gary K Rowe

Dave A Johnston

Frank B Gupton

Young Sek Lo

Robert Frederick Boswell, Jr

Christopher P Johnson, Iii

Ahmad Khodabocus

Kai Oliver Donsbach

Cary Mark Davis

Vithalanand R Kulkarni

Robert C Hughes

Saeed Ahmad

An improved process for making 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3&#x2032;-e][1,4]diazepin-6-one.

Process for making 5,11-Dihydro-11-ethyl-5-methyl-8{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-di pyrido[3,2-b:2',3&#x2032;-e][1,4]diazepin-6-one

The invention provides a multi-step process for preparing 1,2-diamino compounds of formula wherein R, R, R, R, Rand Rhave the meaning given in the specification and pharmaceutically acceptable addition salts thereof, from 1,2-epoxides of formula wherein R, R, Rand Rhave the meaning given in the specification.

Process for preparing 1,2-diamino compounds

The present invention provides a method for preparing S-aryl cysteine. Specifically, the present invention provides enantioselective method for preparing S-aryl cysteine starting from cystine, cysteine or serine amino acid. The methods of the present invention provides S-aryl cysteine in enantiomeric excess of greater than about 96%.

Preparation of S-aryl-cysteine and its derivatives

A Hospital Error-Limiting Program (HELP) directed primarily at reduction of hospital errors in the delivery of medications, goods, services or procedures in patient treatment without a requirement to create patient labels and with the ability to verify frequency of dosage and other treatment specifications. The invention includes a patient wrist identification band with preprinted barcode. The barcode should be selected to correspond with the standard used to barcode unit dose medications. The portable computer should be small in size and equipped with a communication link with the host computer or barcode reader. The portable computer should preferably be coupled directly to the host computer means of the hospital for data transmission by a communication link. The portable computer should be loaded with physician's orders for medications, goods, services or procedures for specific patients. Before medications, goods, services or procedures are administered to a patient, hospital personnel will scan the machine readable code on the patient's identification band, and then the machine readable code on the unit dose(s) of the medications, goods, services, or procedures will be scanned. The portable computer will compare these readings with the doctor's orders and other internal files as required and verify that the administration of the identified medications, goods, services or procedures is either correct or not correct.

Hospital error avoidance system

Growing community of inventors

Moseley, VA, United States of America

Jack Delbert Brown