Smithkline Beecham Corporation

Other

Glaxosmithkline LLC

Jack Dale Leber

John Duncan Elliott

Maria Amparo Lago

Russell Donovan Cousins

Catherine Elizabeth Peishoff

Siegfried B Christensen, Iv

Kelly M Aubart

Mei Li

Joseph Weinstock

Robert A Daines

Ajita Bhat

Martha S Head

John G Gleason

Scott Kevin Thompson

Dirk Andries Heerding

James S Frazee

John D Elliott

Brian E Lock

Jinhwa Lee

Israil Pendrak

Xiangmin Liao

Stacie Marie Halbert

Dimitri E Gaitanopoulos

Sigfried B Christensen, Iv

Tammy J Clark

Igor Safonov

Siegfired B Christensen, Iv

Gerald C Simolike

Novel PDF inhibitors and novel methods for their use are provided.

Peptide deformylase inhibitors

Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors

PDF inhibitors and novel methods for their use are provided.

This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.

Fatty acid synthase inhibitors

This invention relates to certain benzenesulfonamides and their use as PDE7 inhibitors.

Compounds and their use as PDE inhibitors

Novel indane and indene derivatives are described which are endothelin receptor antagonists.

Endothelin receptor antagonists

Indane and indene compounds are described which are endothelin receptor antagonists.

A mixture of beads from a combinatorial library is held in suspension in a liquid by movement of the liquid induced by a vertically reciprocating paddle. The tips of needles in an array are immersed in the suspension, a slot being provided in the paddle to avoid collision with the needles. Liquid is drawn into the needles until a bead becomes attached to the tip of each needle. Excess beads adhering to the needles are shaken off by an electromagnetically operated vibrator, and the beads are deposited in wells of a well plate by applying a short burst of pressure to the interiors of the needles. Liquid and any debris within the needles are thereafter discharged to a receptacle by applying a higher pressure burst to the interiors of the needles.

Apparatus and process for arraying beads

A mixture of beads from a combinatorial library is held in suspension either by inducing circulating flow of a liquid in a tapered vessel by rising air bubbles or by floating the beads at the interface between two immiscible liquids. Beads are selected individually from the suspension by drawing liquid into the tip of a needle having a circular opening smaller than the diameter of a bead. After a bead is captured on the tip of a needle, excess beads are jarred loose or washed away by flow of a solvent through a sheath surrounding the needle, and the needle is moved by a robotic manipulator to a well into which the bead is released.

Growing community of inventors

Collegeville, PA, United States of America

Jack Dale Leber