Genentech, Inc.

F. Hoffmann-la Roche Ag

Jack Alexander Terrett

Huifen Chen

Matthew Volgraf

Elisia Villemure

Robin Larouche-Gauthier

Lea Constantineau-Forget

Francis Beaumier

Luce Lépissier

Claudio F Sturino

Martin Déry

Chantal Grand-Maître

Steven Huy Do

Sushant Malhotra

Jianfeng Xin

Brian Salvatore Safina

Stuart Ward

Daniel Shore

Aijun Lu

Chantal Grand-Maitre

Martin Dery

Steven Do

Chantal Grand-MAÎTRE

Martin DÉRY

Luce LÉPISSIER

Claudio Sturino

The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R, Rand n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Oxadiazole transient receptor potential channel inhibitors

This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

Fused ring compounds

The invention relates to methods of using compounds formula I: and pharmaceutically acceptable salts thereof wherein A, X, R, Rand n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

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South San Francisco, CA, United States of America

Jack Alexander Terrett