Technology Innovations, LLC

National Research Council of Canada

Novocure Gmbh

Sinoveda Canada Inc.

Jack Adam Tuszynski

Yun Kau Tam

Chih-Yuan Tseng

Boguslaw Tomanek

Nancy J Woolf

Stephen H Curry

John Torin Huzil

Sahil Deepak Patel

Aarat Pratyaksh Kalra

Jonathan Y Mane

Karthik Shankar

Dorota Bartusik

Organic light-emitting diodes are disclosed comprising an electron transport layer and a hole transport layer. At least one of the transport layers is formed by (a) dissolving tubulin or microtubules in a mixture of water and a solvent that changes the surface charge of tubulin, wherein the percentage of solvent in the mixture is selected so that the tubulin acquires a desired surface charge, and (b) using the tubulin with the desired surface charge to fabricate the at least one of the transport layers. Advantageously, the solvent may be DMSO. Methods of fabricating such organic light emitting diodes are also disclosed.

Fabricating organic light emitting diodes (OLEDs) using tubulin

The present invention provides a set of in vitro and in silico methodologies for predicting in vivo pharmacokinetics and pharmacodynamics of multiple components; the methodologies comprise mathematical models for solving multiple unknowns which are linearly independent and/or interacting with each other. The present invention can be applied to develop phytomedicines which contain multiple active ingredients without prior identification, isolation and purification of these components.

Pharmaceutical platform technology for the development of natural products

The invention relates to colchicine derivatives, methods and uses thereof for treatment of cancer. In certain embodiments, the colchicine derivative comprises a compound of Formula I: 

Colchicine derivatives, methods and uses thereof

Disclosed in this specification is a method for identifying at least one aptamer that can bind to a bio-molecular target. The aptamer is designed in silico based on the structure of the target molecule. The process includes the steps of determining a first seed residue and growing an oligomer, one residue at a time, while maximizing the entropy of target-oligomer complex or minimizing the binding energy after the addition of each oligomer.

Method for designing an aptamer

A colchicine derivative and a method of using a colchicine derivative as a pharmacological agent in the treatment of malaria are provided.

Compositions and methods for the treatment of malaria

Disclosed is a device which employs a chemically sensitive cantilever hingably attached to a capsule. The cantilever functions as a switch which regulates the flow of particles into and/or out of the capsule.

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Edmonton, Canada

Jack Adam Tuszynski