Dionex Corporation

Elan Pharmaceuticals, Inc.

Dionix Corporation

Jacek J Jagodzinski

Christopher A Pohl

John M Riviello

Rosanne Williamson Slingsby

Maria A Rey

Andrei William Konradi

Christopher Michael Semko

Ying-Zi Xu

Jenifer Lea Smith

Frank Stappenbeck

Charanjit Saini

Kassandra Inez Rossiter

Michael Weitzhandler

Latha P Narayanan

Charanijit Saini

Charaniit Saini

Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof wherein the variables A, n, R, R-Rand Q are defined herein. These compounds bind VLA-4. Certain of these compound also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Imidazolone phenylalanine derivatives

Anion-exchange compositions are provided comprising anion-exchange functional groups comprising at least a first and a second nitrogen group, wherein the first nitrogen group is a quaternary amine and the second nitrogen group is selected from the group consisting of primary, secondary, tertiary or quaternary amines. Methods of making and using the compositions are also provided.

Anion-exchange resins including ion-exchange groups with at least two nitrogen groups, and methods of making and using same

A chromatographic composition for the selective binding of borate ion comprising support resin particle and polymers containing covalently bonded borate binding carbohydrates wherein said carbohydrates are a mono-, di- or polysaccharide of three to seven alcohol moieties per saccharide unit.

Removal of borate in chromatography

In accordance with the present invention, an improved bifunctional cation-exchange composition has been formed which comprises synthetic resin support particles and both crown ether and non-crown ether functional groups attached thereto. The compositions of the present invention provide for novel, enhanced cation separation capabilities and, depending upon the type of functional groups employed, permit effective separation of cations which elute at approximately the same time off standard and commonly used cation-exchange columns. The presently described bifunctional cation-exchange compositions also permit the effective separation of one cation from a mixture comprising another cation that is present at a significantly greater concentration. Formed articles and methods employing the bifunctional cation-exchange composition are also provided.

Bifunctional crown ether-based cation-exchange stationary phase for

In accordance with the present invention, an improved anion-exchange chromatographic composition has been formed which comprises synthetic resin support particles and anion exchange compounds attached thereto, wherein the anion-exchange compounds comprise an internal reactive group, which may be an ester, ketone or amide group, and a terminal quaternary ammonium salt which functions as an anion-exchange site. The compositions of the present invention exhibit improved hydrolytic stability as compared to other known anion-exchange chromatographic compositions due to the presence of linkers which increase the number of atoms separating the internal reactive group from the nitrogen atom of the terminal ammonium anion-exchange site. Formed articles and methods employing the anion-exchange chromatographic composition are also provided.

Hydrolytically stable resins for use in anion-exchange chromatography

In accordance with the present invention, an improved anion- exchange chromatographic composition has been formed which comprises synthetic resin support particles and anion exchange compounds attached thereto, wherein the anion-exchange compounds comprise an internal reactive group, which may be an ester, ketone or amide group, and a terminal quaternary ammonium salt which functions as an anion-exchange site. The compositions of the present invention exhibit improved hydrolytic stability as compared to other known anion-exchange chromatographic compositions due to the presence of linkers which increase the number of atoms separating the internal reactive group from the nitrogen atom of the terminal ammonium anion-exchange site. Formed articles and methods employing the anion-exchange chromatographic composition are also provided.

Growing community of inventors

Redwood City, CA, United States of America

Jacek J Jagodzinski