Instytut Immunologii I Terapii Doswiadczalnej Pan

Instytut Przemyslu Farmaceutycznego

Centrum Baden Molekularnych I Makromolekularnych -pan

Jacek Grodner

Andrzej Kutner

Wieslaw Szelejewski

Wojciech J Stec

Czeslaw Radzikowski

Grzegorz Grynkiewicz

Konrad Misiura

Halina Kusnierczyk

Slawomira Pilichowska

Ryszard Kinas

Process for production of derivatives of 1,3,2-oxazaphosphorinane of general formula 1, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom or 2-halogenoalkyl group, and R.sub.1 and R.sub.2 are not at the same time hydrogen atoms, and X represents halogen atom is based, according to the invention, on the reduction of the respective 3-halogenoacyl derivatives of 1,3,2-oxazaphosphorinane of general formula 2, ##STR2## wherein the substituents have the above given meaning. The reduction is accomplished with the use of sodium borohydride in the presence of boron trifluoride etherate. Derivatives that are prepared by the procedure described here demonstrate antitumor activity.

Process for the production of 1,3,2-oxazaphosphorinanes

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Warsaw, Poland

Jacek Grodner