De Novo Pharmaceuticals Limited

Jac Wijkmans

Raymond Paul Beckett

Barry Porter

Paul Gane

Kenneth Keavey

Lydia Saroglou

Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(&#x2550;O) or of formula C(&#x2550;O)NH(OH); Rrepresents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(&#x2550;O), a hydroxy or amino group; Rrepresents a radical of formula R&#x2014;(X)-(ALK)- wherein Rrepresents hydrogen, or an optionally substituted c-Calkyl, C-Calkenyl, C-Calkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C-Calkylene, C-C6 ?alkenylene, or C-Calkynylene radical, and may be interrupted by one or more non-adjacent NH&#x2014;, &#x2014;O&#x2014; or S&#x2014; linkages, X represents NH&#x2014;, &#x2014;O&#x2014; or S&#x2014;, and m and n are independently 0 or 1; Rrepresents hydrogen, C-Calkyl, or benzyl; and Ris as defined in the specification.

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Oxford, United Kingdom

Jac Wijkmans