Lallemand Hungary Liquidity Management LLC

Valtion Teknillinen Tutkimuskeskus

Stellenbosch University

Danisco Sweeteners Oy

Universiteit Stellenbosch

Jaana Uusitalo

Merja Elisa Penttila

Matti Siika-Aho

Marja Ilmen

Vineet Rajgarhia

John E McBride

Allan C Froehlich

Elena E Brevnova

Mark Mellon

Emily Stonehouse

Riaan Den Haan

Haowen Xu

Kristen M Deleault

Alan Benjamin Gilbert

John S Bardsley

Sanni Voutilainen

Anu Koivula

Deidre Willes

Heikki O Heikkila

Merja Penttilä

Liisa Viikari

Charles F Rice

Anne K Warner

Marja-Leena Sarkki

Heikki Ojamo

Indraneel Shikhare

Emile Van Zyl

Danie Lagrange

Naomi Thorngren

Maija-Leena Vehkomaki

Elena Brevnova

Jim Flatt

Jeff Villari

Alan Froehlich

Dan Murphy

Heidi Hanson Hau

Emily A Stonehouse

Jeffrey D Keating

Chhayal Ghandi

Shaunita Rose

Merja Penttila

The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability ofto produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose

Host cells, comprisingexpressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processes.

A process for producing ethanol from a fibrous lignocellulosic raw material. After pre-treatment of the raw material, the fibrous fraction is first hydrolysed at high consistency and then the modified material is subjected simultaneously to continued hydrolysis with a cellulase and to ethanol fermentation in a fermentation mixture. Fermentation is continued to convert an essential portion of the available cellulose into ethanol, then a liquid fraction containing solubilized hemicelluloses is added to the fermentation mixture and fermentation continued. By means of the invention, high fermentation rates, high ethanol concentrations and low ethanol production costs can be attained.

Process for producing ethanol

The invention relates to a method for the production of xylitol, the method comprising The invention also relates to a microorganism, which has xylanolytic activity and has been genetically modified (i) to enhance its xylanolytic activity, and (ii) to reduce its xylitol metabolism.

Method for the production of xylitol

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Espoo, Finland

Jaana Uusitalo