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Yeda Research and Develpment & Co. Ltd

Jaacov Herzig

Abraham Nudelman

Ehud Keinan

Jeffrey Sterling

Ben Z Weiner

There is provided a novel process for the production of the epipodophyllotoxin glycosides, Etoposide and Teniposide. There are further provided certain novel 4'-demethylepipodophyllotoxin derivatives of the following formula ##STR1## where W is hydrogen or 2,3-di-O-acetyl-4,6,O-ethylidene-D-glucopyran-1-yl. These intermediates are easily transformed into Etoposide and Teniposide and into further derivatives of this series.

Synthesis of podophyllotoxin derivatives

There is provided a process for the selective anomeric deacetylation of sugar derivatives, which may be substituted by substituents such as acetoxy, chloracetoxy, alkoxy, azido, etc., by means of tin compounds R.sub.3 SnOR' or R.sub.2 SnO where R is lower alkyl resulting either directly in the desired anomeric compound or in an intermediate which is converted to the desired compound by silica or by acid hydrolysis.

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Raanana, Israel

Jaacov Herzig