Neurobo Pharmaceuticals, Inc.

University-Industry Cooperation Group of Kyung Hee University

Dong-a St Co., Ltd.

Ja Young Ryu

Jin Seok Jeong

Mi Won Sohn

Sang Zin Choi

Young Woong Cho

So Young Kim

Eun Jin Kim

Hyo Sang Go

Song Hyen Choi

Eunjin Kim

Youngmi Kim

Myung Sook Oh

Hai Hua Jiang

Xiao Fei Du

Byoung Moon Kim

Jeong Soo Kim

Seon-Pyo Hong

The present invention relates to a composition comprising the mixed extract of mulberry andpeel for preventing, improving or treating neurodegenerative disorders. The mixed extract of mulberry andpeel which is the active ingredients contained in the composition of the present invention, has a memory improving activity through inhibiting of acetylcholine esterase and a neuroprotective effects and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.

Composition containing mixed extract of mulberry andbark for preventing, improving or treating neurodegenerative disorders

The present invention relates to a pharmaceutical composition and a food composition for preventing or ameliorating degenerative neurological disease comprisingpeel extract for preventing, or treating neurodegenerative disorders.peel extract which is the active ingredients contained in the composition of the present invention, has a memory ameliorating activity through inhibiting of acetylcholine esterase and a neuroprotective effect and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.

Composition containingpeel extract for treating neurodegenerative disorders

The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

Pharmaceutical composition containing combination extracts of Moutan Root Bark, Angelica Dahurica Root, bupleurum root or fractions thereof for prevention and treatment of neurodegenerative disorder

Composition containing mixed extract of mulberry andpeel

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Seoul, South Korea

Ja Young Ryu