Synphar Laboratories, Inc.

University of Alberta

Taiho Pharmaceutical Company Limited

Altachem Pharma Ltd.

J William Lown

Ronald G Micetich

Weide Luo

Yuqiang Wang

Gerald G Miller

Krzysztof Krowicki

The invention is perylenequinones that are both sonosensitizers and photosensitizers, and their therapeutic use.

Perylenequinones for use as sonosensitizers

Oligopeptide antiretroviral agents are represented by formula (I), wherein A is a moiety bearing a positive charge and of a size which avoids steric inhibition of binding of said compound to nucleic acid sequences associated with the cellular activity of retroviruses; R.sub.1 is a moiety derived from a dicarboxylic acid; Hew is a five-membered heterocyclic moiety; y and z are independently 0, 1, 2 or 3; and x is 0 or 1. These compounds exhibit antiretroviral activity, especially against Human Immunodeficiency Virus (HIV). ##STR1##

Oligopeptide antiretroviral agents

The invention is directed to novel cyclopropylpyrroloindole-oligopeptide compounds which are useful as anticancer agents. The novel cyclopropylpyrroloindole-oligopeptide compounds have the following general structure: ##STR1## wherein, Het.sup.1 and Het.sup.2 are individually selected from the group consisting of pyrrole, imidazole, triazole, thiophene, furan, thiazole, oxazole and pyrazole,

Cyclopropylpyrroloindole-oligopeptide anticancer agents

Oligopeptide anticancer and antiviral agents are represented by the formula:

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Edmonton, Canada

J William Lown