Bayer Aktiengesellschaft

J Urgen Stoltefuss

Siegfried Goldmann

Alexander Straub

Rainer Gross

Martin Bechem

Siegbert Hebisch

Howard-Paul Rounding

Joachim H Utter

Klaus Dembowsky

Michael Negele

Friedrich D Urholz

This invention relates to 3-quinolyl-substituted dihydropyridine derivatives, such as ##STR1## or a pharmaceutically acceptable salt thereof. These compounds are used in treating cardiovascular disease.

3-quinolyl-substituted dihydropyridines, and their use in medicaments

The present invention relates to 4-amino-3-hydroxy-phthalimidine, an important intermediate for the synthesis of 3-substituted 5-quinoline-carboxylic acid amides, and a process for the preparation thereof.

4-amino-3-hydroxy-phthalimidine, and a process for the preparation

Intermediate of the formula ##STR1## wherein R.sup.5 represents a cyclic, straight-chain or branched, saturated or unsaturated hydrocarbon radical having up to 12 carbon atoms, which is optionally interrupted up to twice in an identical or different manner by oxygen or sulphur, as intermediates for substituents on novel dihydropyridine cardiovascular compounds.

3-quinolyl-substituted dihydropyridines, processes for their preparation

The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

4-bicyclically substituted dihydropyridines and their use in medicaments

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Haan, Germany

J Urgen Stoltefuss