Boston Scientific Scimed, Inc.

The Johns Hopkins University

Research Corporation Technologies, Inc.

University of St. Thomas

Vision-ease Lens, Inc.

Exxonmobil Research and Engineering Company

Bmc Vision-ease Lens, Inc.

Boston Scientific Corporation

J Thomas Ippoliti

Robert Warner

Scott Schewe

Gyanu Lamichhane

Gary A Mabbott

Michelle Stohlmeyer

Jeremy Hans

Liliana Atanasoska

Xuzhi Qin

Frank J Hughes

James C Vartuli

Karl Gottlieb Strohmaier

Simon Christopher Weston

Michele L Zoromski

Dan Everson

Joshua Speros

Scott R Schewe

Liliana L Atanasoska

The present invention is a method of treating or preventinginfection in a subject by administering to the subject an effective amount of oxazolidinone, specifically (N—(((S)-3-(dibenzo[b,e][1,4]dioxin-7-yl)-2-oxooxazolidin-5-yl)methyl)acetamide) or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

Oxazolidinone for treatment of infections with

The present invention is a method of treating or preventinginfection in a subject by administering to the subject an effective amount of oxazolidinone, specifically (N&#x2014;(((S)-3-(dibenzo[b,e][1,4]dioxin-7-yl)-2-oxooxazolidin-5-yl)methyl)acetamide) or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

The present invention is a method of treating or preventinginfection in a subject by administering to the subject an effective amount of oxazolidinone, specifically (N-(((S)-3-(dibenzo[b,e][1,4]dioxin-7-yl)-2-oxooxazolidin-5-yl)methyl)acetamide) or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.

Disclosed are oxazolidinone compounds of Formula I: (I) salts thereof, antibacterial pharmaceutical compositions containing them, and use of the compounds to inhibit bacterial growth in mammals, including humans. 

Oxazolidinones and pharmaceutical compositions thereof for treating bacterial infections, including infection of

The present invention pertains, among other things, to polymers having one or more lipophilic hydrocarbon segments and one or more biodegradable polymeric segments, to methods of making such polymers and to products formed using such polymers.

Polymers having lipophilic hydrocarbon and biodegradable polymeric segments

Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.

Nanoparticle precursor structures, nanoparticle structures, and composite materials

Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of &#x2014;C&#x2550;C&#x2014; groups within the polymer backbone, (ii) a plurality of &#x2014;R&#x2014; groups within the polymer backbone, wherein Rcomprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of &#x2014;C&#x2550;C&#x2014; groups and a plurality of &#x2014;R&#x2014; groups within the polymer backbone, (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products are also disclosed.

Medical copolymers

A method of synthesizing a crystalline molecular sieve having an MSE framework type comprises crystallizing a reaction mixture comprising a source of water, a source of an oxide of a tetravalent element, Y, selected from at least one of silicon, tin, titanium, vanadium and germanium, a source of an alkali or alkaline earth metal, M, and a source of organic cations, Q, having the following general structure: in which Ris hydrogen or an alkyl group, and Rand Rare alkyl groups.

Synthesis and use of MSE-framework type molecular sieves

Nanoparticle structures comprising silicon oxide-based polymer, and composite materials

Nanoparticle structures and composite materials comprising a silicon-containing compound having a chemical linker that forms a non-covalent bond with a polymer

A photochromic [1,2-b] naphthopyran having a fluoro substituent in at least one of the 7-position or the 9-position of the naphthopyran provides a stable photochromic compound with a narrow range of absorption. A preferred photochromic naphthopyran has the 2-position of the naphthopyran with two aromatic substituents thereon. It is further preferred to have at least one 2-position aromatic substituent comprising a phenyl group. The photochromic naphthopyran may also have at least one 2-position aromatic substituent comprise a phenyl group having one substituent selected from the group consisting of an anthranilyl, azepinyl, benzoxazolyl, dialkylamino, diazepinyl, diazolyl, imidazolidinyl, imidazolyl, imidazolinyl, indazolyl, indo eninyl, indolinyl, indolizinyl, indolyl, indoxazinyl, isobenzazolyl, isoindolyl, isooxazolyl, isooxazyl, isopyrrol, isoquinolyl, isothiazolyl, julolideno, morpholino, morpholinyl, oxadiazolyl, oxathiazolyl, oxathiazyl, oxathiolyl, oxatriazolyl, oxazolyl, piperazinyl, piperazyl, piperidyl, purinyl, pyranopyrrolyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyrazyl, pyridazinyl, pyridazyl, pyridyl, pyrimidinyl, pyrimidyl, pyridenyl, pyrrolidinyl, pyrrolinyl, pyrroyl, quinolizinyl, quinocyclidinyl, quinolyl, thiazolyl, triazolyl and triazyl group.

Naphthopyran compounds, photoresponsive compositions and lenses

Benzodioxino-naphtho[1,2-b]pyran compounds having particularly advantageous photochromic properties, such as, high sensitivity/coloration, two distinct absorption bands in the 430-500 nm range and 520-620 nm range of the visible spectrum may be generally described as a naphthopyran having a central nucleus of the formula:wherein F is a 1,4-benzodioxine ring

Photochromic benzodioxine fused naphthopyran compounds, compositions and articles containing those naphthopyran compounds

The present invention relates to naphthopyrans, particularly 3,3-&lsqb;substituted&rsqb;-naphtho&lsqb;2,1-b&rsqb;pyrans and 2,2-&lsqb;substituted&rsqb;-naphtho&lsqb;1,2-b&rsqb;pyrans and particularly to novel substitution on the 3-position and 2-position, respectively, of these naphthopyrans. It has been found that there are classes and types of substitution on the 3-position and 2-position (especially combinations of 3,3-substitution and 2,2-substitution) which are novel. Some of these substitutions provide particularly desirable properties. In particular, the present invention relates to naphthopyrans wherein one 3-substituent or one 2-substituent comprises a phenyl group (including phenyl, substituted phenyl, biphenyl or substituted biphenyl) and the other 3-position or other 2-position substituent comprises a substituted or unsubstituted group selected from the group consisting of anthranilyl, azepinyl, benzoxazolyl, diazepinyl, dioazlyl, imidazolidinyl, imidazolyl, imidazolinyl, indazolyl, indoleninyl, indolinyl, indolizinyl, indolyl, indoxazinyl, isobenzazolyl, isoindolyl, isooxazolyl, isooxazyl, isopyrroyl, isoquinolyl, isothiazolyl, morpholino, morpholinyl, oxadiazolyl, oxathiazolyl, oxathiazyl, oxathiolyl, oxatriazolyl, oxazolyl, piperazinyl, piperazinyl, piperazyl, piperidyl, purinyl, pyranopyrrolyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyrazyl, pyridazinyl, pyridazyl, pyridyl, pyrimidinyl, pyrimidyl, pyridenyl, pyrrolidinyl, pyrrolinyl, pyrroyl, quinolizinyl, quinuclidinyl, quinolyl, thiazolyl, triazolyl, and triazyl.

Photochromic substituted naphthopyran compounds

The present invention relates to bis-imidazolyl compounds of the formula: ##STR1## and polymers having the above-identified bis-imidazolyl compounds as a polymerizable unit. The present invention further relates to a method for scavenging trace quantities of metal ions from various effluents sources using the polymers of the instant invention. The instant invention also is directed to the use of the above-identified polymers as corrosion inhibiting agents and as a film for use in gel electrophoresis.

Growing community of inventors

Saint Paul, MN, United States of America

J Thomas Ippoliti