Corixa Corporation

Ribi Immunochem Research, Inc.

J Terry Ulrich

David A Johnson

David H Persing

Jory R Baldridge

Rong Wang

Richard Thomas Crane

Michael J Lacy

Gary T Elliot

Jean S Marshall

Jerry Dolovich

Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.

Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds

Methods and compositions for treating type I immunoglobin E (IgE)-dependent hypersensitivity by the administration of monophosphoryl lipid A (MLA) or 3-deacylated monophosphoryl lipid A (3D-MLA) are disclosed. MLA or 3D-MLA administered alone or in combination with an allergen to a patient suffering from type I hypersensitivity reduces levels of total or allergen specific IgE and increases levels of IgG antibody in that patient. MLA and 3D-MLA can be administered as part of a desensitization regimen or as a component of a prophylactic vaccine to prevent a type I hypersensitivity reaction.

Methods of treating type I hypersensitivity using monophosphoryl lipid A

Growing community of inventors

Corvallis, MT, United States of America

J Terry Ulrich