E. R. Squibb Sons, Inc.

J Scott Wells

Richard B Sykes

Donald R Kirsch

Joseph O'Sullivan

Adrienne A Tymiak

Pacifico A Principe

Carol A Aklonis

Raymond Cooper

Wen C Liu

Helen A Ax

Cultivation of a strain of the microorganism Dactylosporangium sp. A.T.C.C. No. 53693, yields the antibiotic substance EM5586 which contains the novel useful components dactylocycline A and dactylocycline B.

Dactylocycline A and dactylocycline B

Cultivation of the microorganism Chromobacterium violaceum A.T.C.C. No. 31532 yields two novel compounds which have been designated SQ 28,504 and SQ 28,546 in addition to EM5117, a previously disclosed antibacterial compound.

Potentiators of beta-lactam antibiotics

A substance which inhibits the enzyme .beta.-lactamase, produced by a wide range of microorganisms, is obtained when species of the microorganism Micromonospora are cultivated under aerobic fermentation conditions and this inhibitor can be isolated from the fermentation medium by extraction. This substance, denominated EM4615, is useful to enhance the effectiveness of .beta.-lactam antibiotics such as penicillins and cephalosporins.

.beta.-Lactamase inhibitor EM4615

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Ringoes, NJ, United States of America

J Scott Wells