The General Hospital Corporation

J Scott Arn

David H Sachs

Curtis L Cetrulo

Kazuhiko Yamada

Thomas Lorf

Methods of preparing and porcine cells, organs and tissues that have reduced immunogenicity, e.g., for transplant into humans, e.g., for the treatment of burn injuries.

Reducing immunogenicity of xenogeneic transplant tissues

A method of preparing swine donor tissue which includes hematopoietic stem cells and T cells for transplantation into a recipient mammal other than a swine. The method includes the swine donor tissue with an antibody which binds the epitope recognized by the mAb 2-6-15 monoclonal antibody. The binding facilitates depletion of T cells about as efficiently or more efficiently than does the mAb 2-6-15 monoclonal antibody and results in about the same or less depletion of stem cells as does the mAb 2-6-15 monoclonal antibody.

Growing community of inventors

North Andover, MS, United States of America

J Scott Arn