Salsbury Chemicals, Inc.

Provectus Pharmaceuticals, Inc.

J Robert Durrwachter

Eric A Wachter

Timothy C Scott

Jamie Singer

Marlon Lutz

Kevin Babiak

A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100&#xb0; C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

Process for the synthesis of 4,5,6,7-tetrachloro-3',6&#x2032;-dihydroxy-2&#x2032;, 4&#x2032;, 5&#x2032;7&#x2032;-tetraiodo-3H-spiro[isobenzofuran-1,9&#x2032;-xanthen]-3-one (Rose Bengal) and related xanthenes

A process is disclosed for the preparation of an imidazolone and the pharmaceutically acceptable salts thereof having the formula ##STR1## wherein R1 and R2 are the same or different and are C1 to C6 alkyl, C2 to C6 alkenyl, C1 to C6 cycloalkyl, aryl either unsubstituted or substituted with at least one substituent selected from the group consisting of C1 to C6 alkyl, C1 to C6 alkoxy and halo or heteroaryl either unsubstituted or substituted with C1 to C6 alkyl or halo;

Process for preparing oximidazoles

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Charles City, IA, United States of America

J Robert Durrwachter