Ciba-geigy Corporation

Ciba Vision Corporation

J Richard Robertson, Jr

Kai C Su

Frank F Molock

Karl F Mueller

Merrill S Goldenberg

Cheryl R Allen

Copolymers formed from dimethacrylates of polyalkylene glycols and vinylic reactive silicones having up to 20 silicon atoms in the substantial absence of additional cross-linking agents. The copolymers may include a hydrophilicity-modifying monomer. The preferred silicon is TRIS (i.e., 3-methacryloxypropyl tris(trimethylsiloxy) silane), while the preferred polyalkylene glycol is polypropylene glycol dimethacrylate. The copolymers are especially suited to use in the fabrication of soft contact lenses because of the good durability and high oxygen permeability and transmissibility. Oxygen transmissibilities of greater than 70 barrers/mm are preferred.

Silcone-containing polymer having oxygen permeability suitable for

Antimicrobial quaternary ammonium group-containing organosilicon polymers, aqueous disinfectant solutions containing such polymers, and lenses produced from such polymers are provided herein. The polymers are produced by homopolymerizing or copolymerizing, with a suitable comonomer, a quaternary ammonium group-containing organosilicon monomer having, for example, the following structure: ##STR1##

Monomers for producing antimicrobial quaternary group-containing polyers

Antimicrobial quaternary ammonium group-containing organo-silicon polymers, aqueous disinfectant solutions containing such polymers, and lenses produced from such polymers are provided herein. The polymers are produced by homopolymerizing or copolymerizing, with a suitable comonomer, a quaternary ammonium group-containing organosilicon monomer having, for example, the following structure: ##STR1##

Antimicrobial quaternary ammonium group-containing polymers,

Hydrophilic modifier monomers of the formula [X-T].sub.z' H' are disclosed wherein X is a reactive group, H' is a hydrophilic group and T is a divalent linking group, z' being a number up to the available valence of H', excess H' valences being taken up by hydrogen. The monomers of the invention can be used to boost the hydrophilic nature of a wide variety of polymeric materials or be polymerized themselves with varying degrees of copolymerizable monomers. They are particularly suited for making hydrophilic contact lens materials.

Hydrophilic modifier monomers

Contact lenses which are optically clear, wettable, flexible, and of high oxygen permeability in the aqueous ocular environment of use, of a block copolymer containing polysiloxane and polyoxyalkylene oxide units are disclosed, as well as the preparation thereof and methods of treating vision defects therewith.

Wettable, flexible, oxygen permeable contact lens containing block

Contact lenses which are optically clear, wettable, of high oxygen permeability and substantially non-swellable in the aqueous ocular envionment of use, of a block copolymer containing polysiloxane and polyoxyalkylene oxide units are disclosed, as well as the preparation thereof and methods of treating vision defects therewith.

Wettable, rigid gas permeable, substantially non-swellable contact lens

Hydrophilic modifier monomers of the formula [X--T].sub.z 'G' are disclosed wherein X is a reactive group, G' is a hydrophilic group and T is a divalent linking group, z' being a number up to the available valence of G', excess G' valences being taken up by hydrogen. The monomers of the invention can be used to boost the hydrophilic nature of a wide variety of polymeric materials or be polymerized themselves with varying degrees of copolymerizable monomers. They are particularly suited for making hydrophilic contact lens materials.

Glutarimido and succinimido derivatives

Hydrophilic modifier monomers of the formula [X-T].sub.z' G are disclosed wherein X is a reactive group, G is a hydrophilic group and T is a divalent linking group, z' being a number up to the available valence of G, excess G valences being taken up by hydrogen. The monomers of the invention can be used to boost the hydrophilic nature of a wide variety of polymeric materials or be polymerized themselves with varying degrees of copolymerizable monomers. They are particularly suited for making hydrophilic contact lens materials.

Hydrophilic modifier monomers of the formula [X-T].sub.z 'G are disclosed wherein X is a reactive group, G is a hydrophilic group and T is a divalent linking group, z' being a number up to the available valence of G, excess G valences being taken up by hydrogen. The monomers of the invention can be used to boost the hydrophilic nature of a wide variety of polymeric materials or be polymerized themselves with varying degrees of copolymerizable monomers. They are particularly suited for making hydrophilic contact lens materials.

Contact lenses which are optically clear, wettable, flexible, of high oxygen permeability and substantially non-swellable in the aqueous ocular environment of use, of a block copolymer containing polysiloxane and polyoxyalkylene oxide units are disclosed, as well as the preparation thereof and methods of treating vision defects therewith.

Growing community of inventors

Alpharetta, GA, United States of America

J Richard Robertson, Jr