Stolle Research & Development Corporation

Stolle Milk Biologics, Inc.

Argyll Biotechnologies, Llc.

J Peter Fuhrer

Lee R Beck

James D Thacker

Kenneth O Willeford

A new class of lipopeptides has been surprisingly discovered from mammalian serum that are potent immunoregulators, hereinafter, referred to as Immune Cell Potentiating Factors ('ICPF's). The clinical and laboratory data show a wide range of prophylactic and therapeutic applications for the ICPFs including primary and adjunctive therapy in the treatment of diseases of both bacterial and viral origin as well as certain neoplastic diseases. Described herein are chemical structures of ICPF of the invention, the likely mode of action, and the surprisingly broad spectrum of therapeutic efficacy and wide margin of safety to the host species.

Prophylactic and therapeutic benefits of a new class of immune stimulating peptides

The invention relates to an anti-inflammatory factor isolated from milk, methods of purifying the anti-inflammatory factor resulting in substantially or highly purified preparations and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.

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Dayton, OH, United States of America

J Peter Fuhrer