Angiodynamics, Inc.

Interface Biologics, Inc.

Ripple Therapeutics Corporation

Evonik Canada Inc.

Other

Mount Sinai Hospital Corporation

Sinai Health System

J Paul Santerre

Jeannette Ho

Raymond Lareau

Benjamin Bell

Roseita Esfand

Sanjoy Mullick

Ian Charles Parrag

Hans Christian Fischer

Wendy Alison Naimark

Kyle Giovanni Battiston

Matthew Alexander John Statham

Dimitra Louka

Weilun Chang

Rita A Kandel

Alexandra Piotrowicz

Bernadette Ilagan

Meilin Yang

Sylvia Tjahyadi

William M Appling

Theodore J Beyer

Robert M Pilliar

Carol L Lancette

Richard Witmeyer

Mei Li

Mark John Ernsting

H Hung Pham

Vivian Z Wang

Jamie Robert Swenor

Jenshong Hong

Shu Qiu Li

Antonio Cillero Rodrigo

Kyle William Macdonald

Mark J Ernsting

The present invention relates to polyvinvyl chloride (PVC) admixtures with plasticizers and surface modifying macromolecules. In accordance with embodiments, articles formed from the compositions disclosed herein may reduce leaching of plasticizers.

Plasticized PVC admixtures with surface modifying macromolecules and articles made therefrom

The invention relates to carbonate-linked surface modifying macromolecules and admixtures thereof. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules).

Carbonate-linked surface modifying macromolecules

The invention relates to ester-linked surface-modifying macromolecules and admixtures thereof as shown below by the representative compounds. The admixtures can be used in industrial and medical applications where enhanced surface properties are desirable (e.g., surface properties reducing or preventing biofouling, immobilization of biomolecules, or denaturation of certain biomolecules). 

Ester-linked surface modifying macromolecules

The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Dexamethasone prodrug compositions and uses thereof

The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

Glass formulations and uses thereof

The disclosure relates to an intervertebral disc implant comprising a first construct comprising a continuous layer of nucleus pulposus (NP) tissue directly or indirectly on and integrated with a substrate, and a second construct surrounding the first construct comprising one or more continuous layers of annulus fibrosus (AF) tissue on and adherent to a scaffold, wherein the AF tissue, which is composed of single or multiple adherent layers, is integrated with the NP tissue. The disclosure also relates to methods of preparing the multi-tissue intervertebral disc and using the intervertebral disc as an implant.

Intervertebral disc implant

The invention relates to oligofluorinated coatings and their use in drag delivery. The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue. This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.

Local delivery of drugs from self assembled coatings

The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.

Oligofluorinated cross-linked polymers and uses thereof

A vascular access catheter is disclosed that has a catheter shaft with a distal end portion with a distal tip having a sloped face that is positioned at an acute angle from the distal tip relative to a longitudinal axis of the catheter shaft. A first, second, and third lumen extend longitudinally through the catheter shaft. The third lumen is configured for receiving a guidewire and may extend a partial length of the catheter or substantially the entire length of the catheter. The first lumen has an aperture located in the angled edge distal end portion of the catheter next to the distal tip and communicates with the first lumen. The second lumen has an aperture that is positioned in the outer surface of the catheter shaft that is in communication with the second lumen, and is spaced proximally from the first lumen aperture. The catheter includes a fluoropolymer additive with specific compositions and/or purity levels.

Dialysis catheters with fluoropolymer additives

A venous access catheter shaft and method of using and manufacturing such a catheter is provided. In one aspect of the invention, a catheter is provided comprising a base polymer having a Shore A durometer of 85A or lower, with 2.0% percent by weight of surface modifier, and a radiopaque filler comprising between 20-40 percentage by weight. In another aspect of the invention, a method reducing thrombus accumulation on a venous access catheter is provided wherein the catheter surface's resistance to thrombus formation is enhanced during indwell time by lowering the durometer rating of the base polymer of the catheter without increasing the amount of surface modifier additive. In another aspect of the invention, a method of manufacturing a catheter shaft is provided, wherein the shaft is formed comprising a base polymer having a Shore A durometer of 85A or lower, with 2.0% percent by weight of surface modifier, and a radiopaque filler comprising 30% by weight barium sulfate, and optionally a colorant of 0.2% weight.

Catheter shaft with enhanced platelet anti-adhesion surfaces

The invention relates to admixtures of thermoplastic polyurethane base polymers that resist surface dulling and fluorinated additives and their use in the manufacture of articles, such as medical devices. For example, the admixtures of the invention are useful in the manufacture of blood dwelling medical devices, such as catheters.

Thermoplastic polyurethane admixtures

The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels.

Catheters with high-purity fluoropolymer additives

Growing community of inventors

Whitby, Canada

J Paul Santerre