Alkermes Controlled Therapeutics, Inc. Ii

Alkermes Pharma Ireland Limited

Alkermes, Inc.

Cerulean Pharma Inc.

Alkermes Controlled Therapeutics, Inc.

Novartis Ag

Janssen Pharmaceutica

Placon Therapeutics, Inc.

Alkermes Controlled Therapeutics, Inc. I

J Michael Ramstack

Steven G Wright

Joyce M Hotz

Shawn L Lyons

Michael E Rickey

David A Dickason

Harry G Brittain

Danny H Lewis

Rajesh Kumar

John Podobinski

Stephen E Zale

OluFunmi Lily Johnson

M Gary I Riley

David S Dickey

Mark T Bilodeau

Rossitza Gueorguieva Alargova

Jean Louis Mesens

Benoît Moreau

Paul F Herbert

Richard Wooster

Thomas J Atkins

Thomas Crawford

Patrick Lim Soo

Kerry Whalen

Danielle N Rockwood

Linda M Custer

Jan Strobel

Sukhjeet Singh

Tsun P Au Yeung

M Gary Riley

Stephan E Zale

Processes for precipitating polymers from a polymer-containing solution are disclosed.

Methods and systems for polymer precipitation and generation of particles

The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.

Platinum compounds, compositions, and uses thereof

This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.

Polymorphic forms of naltrexone

Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., &#x3b1;-cyclodextrin, &#x3b2;-cyclodextrin, and &#x3b3;-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.

This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.

Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.

Method for fabricating nanoparticles

In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Methods and systems for generating nanoparticles

Growing community of inventors

Lunenburg, MA, United States of America

J Michael Ramstack