Hainan University

J Michael McIntosh

Xiaopeng Zhu

Yuanyan Hu

Dongting Zhangsun

Sulan Luo

Yong Wu

Hui Bing

The present invention pertains to fields of biochemistry and molecular biology, relates to an &#x3b1;O-superfamily conotoxin peptide, pharmaceutical composition thereof, preparation method and use thereof. The present invention further relates to a propeptide of the conotoxin peptide, nucleic acid construct thereof, expression vector and transformed cell thereof, and fusion protein thereof. The present invention further relates to a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The new &#x3b1;O-superfamily conotoxin peptide of the present invention is capable of specifically blocking acetylcholine receptor (nAChRs) (e.g., &#x3b1;9&#x3b1;10 nAChR), and NMDA receptor (e.g., NR2C NMDAR), and has activity for treatment of neuralgia, addiction, and activity for treatment of chemotherapy of cancers, breast cancer, lung cancer, wound healing, epilepsia, ischemia, and thus is promising in the manufacture of analgesic, a medicament for treatment of addiction, and a tool drug for neuroscience.

&#x3b1;O-superfamily conotoxin peptide, pharmaceutical composition and use thereof

The present invention provides a novel &#x3b1;-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The &#x3b1;-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as &#x3b1;3&#x3b2;2 nAChRs, &#x3b1;6/&#x3b1;3&#x3b2;2&#x3b2;3 nAChR or &#x3b1;3&#x3b2;4 nAChR or &#x3b1;6/&#x3b1;3&#x3b2;4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

&#x3b1;-conotoxin peptide, pharmaceutical composition and use thereof

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Haikou, China

J Michael McIntosh