Merrell Dow Pharmaceuticals

Richardson-merrell Inc.

Merrell Pharmaceuticals, Inc.

Hoechst Marion Roussel

J Martin Grisar

Richard C Dage

Richard A Schnettler

George P Claxton

Frank Bolkenius

Margaret A Petty

Thomas R Blohm

Roger A Parker

Norbert L Wiech

Frank P Palopoli

Gilbert Marciniak

Robert D MacKenzie

Derivatives of 2,3-dihydro benzofuranols

Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans

Cardioprotective agents

This invention relates to quaternary ammonium salts of certain 2H-1-benzopyran derivatives, to the intermediates and processes useful for their preparation, to their free-radical scavenger and cellular protective properties and to their end-use application as therapeutic agents.

Cardioprotective tocopherol analogs

This invention relates to alkylated sulfonium alkylene derivatives of certain 2H-1-benzopyrans, to the intermediates and processes useful for their preparation, to their free-radical scavenger and cardioprotective properties and to their end-use application as therapeutic agents.

Tissue protective tocopherol analogs

Derivatives of 3,4-dihydroxy-2,5-dihydrofuran-5-ones, intermediates and processes useful for their preparation are disclosed. These compounds are useful as free-radical scavengers and exhibit cellular protective properties.

Ascorbic acid derivatives

Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.

Cardiotonic aroylthiazolones

A sulfur analog of enoximone, 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-thione, is reported to reduce reperfusion injury, the injry which occurs when molecular oxygen is reintroduced into an ischemic tissue. The compound could be used to prevent much of the damage which occurs to the heart of a heart attack victim.

Reducing reperfusion injury with

Novel alkanoylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.

Cardiotonic alkanoylthiazolones

Cardiotonic aroylthiazolones and the use thereof

Heterocyclocarbonyl- and acetyl-thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.

Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones

Pyrrole-3-carboxylates of the following general structure ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl group; R.sub.2 is a 1 to 8 carbon atom alkyl group; and R.sub.3 is a hydrogen, lower alkyl, pyridyl, pyridylmethyl, pyrryl, pyrrylmethyl, thienyl, thienylmethyl or phenyl or benzyl optionally substituted with one or two lower alkyl, lower alkoxy, lower alkylthio, halogen, nitro, hydroxy, carboxy or cyano groups or with a methylenedioxy group.

Pyrrole-3-carboxylate cardiotonic agents

1,3-Dihydro-2H-imidazol-2-ones having 5-acyl and 4-oxymethyl substituents, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate alcohol or a silver salt with a substituted 4-bromomethyl-1,3-dihydro-2H-imidazol-2-one.

[1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates

4-alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.sub.1 is hydrogen or lower alkyl; R.sub.2 is a lower aliphatic hydrocarbon radical, phenyl alkylene or heterocyclo alkylene; and the pharmaceutically acceptable salts thereof.

Growing community of inventors

Cincinnati, OH, United States of America

J Martin Grisar