Affymetrix, Inc.

Affymax Technologies, N.v.

J. Leighton Read

Michael C. Pirrung

Lubert Stryer

Stephen P. A. Fodor

Affymax N.v.

J Leighton Read

Michael C Pirrung

Stephen P A Fodor

Stephen P Fodor

Paul D Hoeprich, Jr

Stephen Pa Fodor

Luburt Stryer

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Nucleotides and analogs having photoremovable protecting groups

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Apparatus comprising polymers

The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.

Polypeptide arrays

A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.

Methods for polymer synthesis

Apparatus for polymer synthesis

Nucleic acid reading and analysis system

Methods of synthesizing a plurality of different polymers on a surface of a substrate

Support bound probes and methods of analysis using the same

Methods of making nucleic acid or oligonucleotide arrays

Very large scale immobilized polymer synthesis

A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a second predefined region of the substrate. The irradiation step removes a protecting group therefrom. The substrate is contacted with a first nucleotide to couple the nucleotide to the substrate in the first predefined region. By repeating these steps, an array of diverse oligonucleotides is formed on the substrate.

Apparatus for forming polynucleotides or polypeptides

Photolithographic and other means for manufacturing arrays

A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group; is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.

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Palo Alto, CA, United States of America

J Leighton Read