Biomerieux Vitek, Inc.

Biomerieux, Inc.

Amoco Corporation

J Lawrence Burg

Luigi Catanzariti

Marcela Vera-Garcia

James G Moe

Bryan W Kluttz

Geoff A McKinley

Luigi Catanzarit

The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.

Nucleic acid assays

The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance for contamination from manipulation of reagents, internal controls for amplification, and the use of automated apparatus for the automated detection of one, or more than one amplified nucleic acid sequences.

Device for automated detection of nucleic acids

Novel insertion elements, recombinant molecules and amplifiable nucleic acids and methods for making them are disclosed. The insertion elements and amplifiable nucleic acids can be used with nucleic acid hybridization assays. Also disclosed are libraries of the novel insertion elements, recombinant molecules and amplifiable nucleic acids and the use of such libraries in identifying preferred insertion elements, recombinant molecules and amplifiable nucleic acids of the invention.

Insertion elements and amplifiable nucleic acids

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Framingham, MA, United States of America

J Lawrence Burg