Cryomedical Sciences Inc.

J J Finkelstein

John G Baust

Boris Rubinsky

Gary M Onik

ZhaoHua Chang

Dan Neu

Steve Jones

Zhao H Chang

An improved cryosurgical system includes means for cooling the cryoprobe instrument to temperatures below the normal boiling point of liquid nitrogen as well as means for recovering the sub-cooled liquid coolant. A unique cryoprobe instrument of simplified construction uses an active vacuum for thermal insulation. Means are provided for controllably adjusting the length of the freezing zone of the cryoprobe to allow the freezing zone to be adjusted for different sizes and shapes of tumors which may be 'observed' before surgery by ultrasound imaging. Multiple, disposable cryoprobe instruments can be individually controlled for both operating temperature and freeze zone length. A preferred refrigeration system for sub-cooling liquid nitrogen refrigerant or other cryogenic liquid refrigerant is based on the principles of evaporative cooling.

Cryosurgical instrument and system and method of cryosurgery

A cryogenic surgical instrument and method of manufacturing the same are described. The instrument is a cryosurgical probe having concentrically arranged cryogenic fluid supply and return tubes extending through a concentric handle portion into a closed end probe shaft wherein the handle portion and a substantial length of the probe shaft are evacuated to provide a layer of thermal insulation between the cryogenic fluid supply and return tubes and the exterior of the instrument. All the parts of the probe structure are joined by vacuum brazing method carried out in an evacuated furnace. The method involves assembling the probe parts into sub-assemblies which are vacuum brazed at a temperature of at least about 1000.degree. F. and a vacuum of at least about 1.times.10.sup.-3 Torr. The sub-assemblies are then assembled into the final probe assembly which is likewise vacuum brazed. The final vacuum brazing step simultaneously draws a vacuum within the handle portion and probe shaft through small gaps between the junctions of the sub-assemblies or via a heat sealable valve which is sealed by the brazing method thereby maintaining the vacuum within the handle and probe shaft for thermal insulation. The strength and hardness of the probe shaft may be increased by cold-working, particularly by a combination of swaging and shot-peening. Probe shafts of curved configurations may also be formed. Multiple sub-assemblies and final assemblies can be formed at the same time in a vacuum brazing furnace.

Cryogenic surgical instrument and method of manufacturing the same

A closed end surgical cryoprobe instrument may have a probe shaft diameter of 3 millimeters or less and can achieve and maintain freezing zone temperatures close to that of the liquid cryogenic refrigerant. Using sub-cooled liquid nitrogen at approximately -208.degree. C. freezing zone temperatures as low as -206.degree. C. can be achieved in under 1 minute. The liquid nitrogen supply tube is provided with a plurality of small vent holes to vent gas formed or present in the refrigerant supply tube to the return refrigerant flow channel. The vent holes also allow small amount of liquid nitrogen to vent into the return flow channel to further reduce the temperature differential between the sub-cooled liquid nitrogen supply and the counter current flowing return refrigerant. Heat transfer is maintained through nucleate boiling. In place of vent holes, narrow slits may be provided in the supply tube. Alternatively, a sintered porous metal supply tube can be used as the vent means.

Cryosurgical instrument with vent means and method using same

Cryosurgical system for destroying tumors by freezing

A closed end surgical cryoprobe instrument with probe shaft diameter of 3 millimeters or less is made to achieve and maintain freezing zone temperatures close to that of the liquid cryogenic refrigerant. Using sub-cooled liquid nitrogen at approximately -208.degree. C. freezing zone temperatures as low as -206.degree. C. can be achieved in under 1 minute. The liquid nitrogen supply tube is provided with a plurality of small vent holes to vent gas formed or present in the refrigerant supply tube to the return refrigerant flow channel. The vent holes also allow small amount of liquid nitrogen to vent into the return flow channel to further reduce the temperature differential between the sub-cooled liquid nitrogen supply and the counter-current flowing return refrigerant.

Growing community of inventors

Bethesda, MD, United States of America

J J Finkelstein