Excaliard Pharmaceuticals, Inc.

Isis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

Virtual Arrays, Inc.

J Gordon Foulkes

Nicholas M Dean

Niall O'Donnell

C Frank Bennett

Susan M Frier

Susan M Freier

Gregory E Hardee

Leroy Young

Lincoln Krochmal

Mark Jewell

Oren E Beske

Niall O'donnell

Niall O`DONNELL

This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

Antisense oligonucleotides directed against connective tissue growth factor and uses thereof

This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.

Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)

Methods for inhibiting expression of connective tissue growth factor

Systems for multiplexed analysis of gene expression using coded RNA reporters. The coded RNA reporters are expressed from a library of reporter genes, with each reporter gene directing expression of a distinguishable coded RNA reporter. Each RNA reporter thus reports activity of a corresponding reporter gene. The distinguishable reporter RNA species allow otherwise similar reporter genes to be functionally linked to different effectors within a cell reporter library. Multiplexed analysis of reporter gene activity is carried out by measuring the level of each RNA reporter within the cell reporter library, thus providing an ability to analyze the effect of a biological modulator on many effectors.

Biological assays using coded RNA reporters

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Encinitas, CA, United States of America

J Gordon Foulkes