Schering Corporation

Merck Sharp + Dohme Corp.

J Fernando Bazan

Robert A Kastelein

Rene De Waal Malefyt

Jacqueline C Timans

Yong-Jun Liu

Albert Zlotnik

Daniel M Gorman

Gerard T Hardiman

Kevin W Moore

Gerard Zurawski

Donna M Rennick

Stefan Karl-Heinz Pflanz

Jeanne Cheung

Thomas J Schall

Devora L Rossi

Kevin B Bacon

Vassili Soumelis

Pedro A Reche-Gallardo

Chuan-Chu Chou

Jimmy C Tan

Di-Hwei Hsu

Ying Liu

Alice Suk-Yue Ho

Fernando L Rock

Christi L Parham

Nicholas J Murgolo

Theodore R Sana

Birgit Oppmann

Stephen W K Ho

Vassilli Soumelis

Johannes Eduard Maria Antonius Debets

Terrill K McClanahan

Martin Oft

Joseph A Hedrick

Scott W Altmann

Jacqueline L Kennedy

M Jorge Guimaraes

Jochen Schmitz

M Jorge Guimar&atilde;es

Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.

Methods of modulating cytokine activity; related reagents

Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

Antibodies to IL-B50

Purified genes encoding a cytokine referred to as interleukin-B30 (IL-B30) from a mammal, and reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.

Interleukin-B30 proteins

Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.

Binding compounds for IL-27

Purified genes encoding interleukin-B30 from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

IL-B30 antibodies

Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.

Method for blocking binding of CX3C chemokines using CX3C chemokine antibodies

Purified genes encoding cytokine referred to as interleukin-B30 (IL-B30) from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

IL-D80 polynucleotides

Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.

Method of treatment using an anti-IL-B50 antibody

IL-B50 polypeptide

CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.

Nucleic acids encoding murine IL-174

IL-D80 polypeptides and IL-27

Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.

DIRS1 polypeptides

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Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.

Human DNAX toll-like receptor 4 proteins, related reagents and methods

Growing community of inventors

Menlo Park, CA, United States of America

J Fernando Bazan