Carnegie Mellon University

J Dinithi Rashmini Perera

Danith H Ly

Shivaji A Thadke

Ali Nakhi

Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a &#x3b3;-peptide nucleic acid (&#x3b3;PNA). Also provided are genetic recognition reagents comprising one or more of the divalent nucleobases and a nucleic acid or nucleic acid analog backbone, such as a &#x3b3;PNA backbone. Uses for the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.

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Pittsburgh, PA, United States of America

J Dinithi Rashmini Perera