Genaissance Pharmaceuticals, Inc.

J Claiborne Stephens

Richard S Judson

Andreas Windemuth

Krishnan Nandabalan

Stephen Bryant Liggett

Gualberto Ruaño

R Rex Denton

Chuanbo Xu

Catherine B Stack

Connie M Drysdale

Methods, computer program(s) and database(s) to analyze and make use of gene haplotype information. These include methods, program, and database to find and measure the frequency of haplotypes in the general population; methods, program, and database to find correlation's between an individual's haplotypes or genotypes and a clinical outcome; methods, program, and database to predict an individual's haplotypes from the individual's genotype for a gene; and methods, program, and database to predict an individual's clinical response to a treatment based on the individual's genotype or haplotype.

Methods for obtaining and using haplotype data

Genotypes and haplotypes for thirteen polymorphic sites in the &bgr; -adrenergic receptor (&bgr; AR) gene are disclosed. Compositions and methods for predicting genetic predisposition to disease associated with polymorphic sites in the (&bgr; AR) gene, as well as for predicting response to &bgr;-agonists, are also disclosed.

Association of &bgr;2-adrenergic receptor haplotypes with drug response

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Guilford, CT, United States of America

J Claiborne Stephens