Bristol-myers Squibb Compnay

J Alex Bates

Jeremy M Richter

Eldon Scott Priestley

Xiaojun Zhang

Oz Scott Halpern

Daniel L Cheney

Samuel Kaye Reznik

Disclosed are compounds of Formula (I) to (VIII): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein Ris a bicyclic heteroaryl group substituted with zero to 3 R; and R, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

Bicyclic heteroaryl substituted compounds

The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments. 

3-sulfonyl-5-aminopyridine-2,4-diol APJ agonists

The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments. 

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Hillsborough, NJ, United States of America

J Alex Bates